Results 111 to 120 of about 2,815,885 (243)

“So agreeable and suitable a place”: a late eighteenth-century suburban villa [PDF]

open access: yes, 2014
The suburban villa rose to prominence in the eighteenth century. Burlington, Pope and others built large houses on the outskirts of London as expressions of their wealth and taste, using them to showcase collections, entertain friends or escape from the ...
Stobart, Jon
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Development Of Learning Material Of Pakem-Plus For Mathematics Lesson At Elementary School [PDF]

open access: yes, 2011
Active, creative, effective, and enjoy full learning (PAKEM) needs to be supported by good teachers’ understanding about both of content and choosing context.
Rahmah , Johar
core  

Relevance, Resonance, and Historiography: Interpreting the Lives and Experiences of Civil War Soldiers

open access: yes, 2016
Carmichael shares his experiences of portraying Corporal Bobby Fields at Appomattox Court House National Historical Park in the summer of 1985. He uses Fields as a conduit to explore the scholarship pertaining to the common soldier of the Civil War and ...
Carmichael, Peter S.
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Through the lens of color: Relationships between color properties and visual perception of wood (Acer.) figures

open access: yesMaterials & Design
The wood figure is a crucial wood trait that contributes to its versatile applications, drawing attention and inspiring imagination. This study aims to elucidate the impact of color attributes on the visual perception of wood figures.
Jiapei Qin   +5 more
doaj   +1 more source

The political life of things: Explorations on material culture and consumption in Evangelical groups in Buenos Aires, Argentina [PDF]

open access: yes, 2017
The aim of the article is to explore the material culture of Neo-Pentecostals´ mega-churches in Buenos Aires City, Argentina. In order to do this, we will reconstruct three consumers’ profile and the way that political senses are put into play.
Algranti, Joaquin Maria
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Pedagogies of Race: The Politics of Whiteness in an African American Studies Course [PDF]

open access: yes, 2011
This paper evaluates students\u27 arguments for a color-blind society to avoid discussions related to the continued existence of racism in USA culture.
Jones, Regina V.
core   +1 more source

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