Results 111 to 120 of about 10,287,445 (293)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Yakov A. Sher (1931–2019): Milestones of Academic Career
СибСкриптProfessor Yakov A. Sher (1931–2019), Doctor of History, was a world-famous specialist in prehistoric art. This research relied on the archives of the Institute for Material Culture History, the State Hermitage Museum, and the Kemerovo State University to
Lyudmila Yu. Kitova +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Clan Crypts on the Lower Don of the Early Catacomb Time and Genesis Issues of the Catacomb Rite
Нижневолжский археологический вестникThe article provides comprehensive information about two Middle Bronze Age burials (No. 26, 42) from the kurgan 1 in the burial mound Vesely I near Novocherkassk in the Rostov region. The burials contained double tombs with a complex rite and prestigious
Alexey V. Kiyashko
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Нижневолжский археологический вестникIn the first quarter of the 21st century, it became possible to expand research on the key issues of ancient metallurgy and metalworking, as well as related social and cultural processes, based on the database accumulated by Bronze Age archaeology ...
Aleksey Kiyashko
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
A quantitative workflow for modeling diversification in material culture. [PDF]
PLoS One, 2020 Gjesfjeld E +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source