Results 111 to 120 of about 1,336,966 (305)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Clan Crypts on the Lower Don of the Early Catacomb Time and Genesis Issues of the Catacomb Rite
Нижневолжский археологический вестникThe article provides comprehensive information about two Middle Bronze Age burials (No. 26, 42) from the kurgan 1 in the burial mound Vesely I near Novocherkassk in the Rostov region. The burials contained double tombs with a complex rite and prestigious
Alexey V. Kiyashko
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Material Culture Research: Authentic Things, Authentic Values
, 1997 Over the past twenty-five years, a number of themes have governed material culture research. Objects were often chosen for research because they expressed meaningful identities — personal, regional or national. While earlier studies focussed on creation,
Pocius, Gerald L.
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Materials & DesignThe wood figure is a crucial wood trait that contributes to its versatile applications, drawing attention and inspiring imagination. This study aims to elucidate the impact of color attributes on the visual perception of wood figures.
Jiapei Qin +5 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Bulletin d'histoire de la culture matérielle #08
, 1979 Introduction. Remarks at the opening session of Canada's Material History: a Forum by F. J. Thorpe. -- Culture matérielle et histoire par Jean-Pierre Wallot. -- Multidisciplinary dimensions in material history by John J. Mannion.
core