Results 91 to 100 of about 2,815,885 (243)

Current Research: Toward a Collaborative Development of a Truly Comprehensive Multi-State Material Culture Database [PDF]

open access: yes, 2018
Throughout the past several years, I have been compiling, with the help of several Caddo researchers, a comprehensive multi-state database primarily composed of whole Caddo vessels from published excavations, private collections, and archaeological ...
McKinnon, Duncan P.
core   +1 more source

Service evaluation to establish the sensitivity, specificity and additional value of broad-range 16S rDNA PCR for the diagnosis of infective endocarditis from resected endocardial material in patients from eight UK and Ireland hospitals [PDF]

open access: yes, 2014
Infective endocarditis (IE) can be diagnosed in the clinical microbiology laboratory by culturing explanted heart valve material. We present a service evaluation that examines the sensitivity and specificity of a broad-range 16S rDNA polymerase chain ...
Alshafi, K   +8 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Writing In and Around Video Games [PDF]

open access: yes, 2015
This undergraduate course uses video games as a lens through which to explore the infinitely broader topic of digital rhetoric. Students encounter games in several different ways: as texts to analyze, raw material for video compositions, systems to ...
Sierra, Wendi
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Исследование «пещерного города» Эски-Кермен в 20-е — 30-е годы XX века / The research of the Eski-Kermen “cave town” in the 20's and 30's of the 20th century

open access: yesМатериалы по археологии и истории античного и средневекового Крыма, 2016
Целью исследования стало освещение малоизученных моментов истории изучения «пещерного города» Эски-Кермен. В предлагаемой вашему вниманию статье пойдет речь об исследовании этого памятника истории и культуры, проведенного экспедицией ГАИМК, а также ...
N.A. Abramova
doaj  

Metaphors and Metaphysics [PDF]

open access: yes, 2003
Culture is a net of information exchange basing upon messages. To say anything about understanding within cultural communication one should study the very structure of a message. It seems that any message consists in at least five elements: sending – a
Bolińska, Ewa
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

A short history of the Oral History society, c. 1973–2013

open access: yesWrocławski Rocznik Historii Mówionej, 2013
W 2013 r. Stowarzyszenie Historii Mówionej obchodziło swoją czterdziestą rocznicę istnienia. Odegrało ono bardzo znaczącą rolę w rozwoju dziedziny historii mówionej (oral history), szczególnie w Wielkiej Brytanii.
Graham Smith
doaj   +1 more source

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