Results 91 to 100 of about 10,287,445 (293)

Spanishness and Race in North American Monumental Architecture

Arts
The representation of Spain, and Spanishness in general, at sites of collective identity in the United States and Canada requires scholarly attention. Many monuments, which range from statues and museums to capitol buildings and national parks, continue ...
Lauren Beck
doaj   +1 more source

The parietal lobe evolution and the emergence of material culture in the human genus. [PDF]

Brain Struct Funct, 2023
Bruner E, Battaglia-Mayer A, Caminiti R.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The impact of aging method on the age-at-death distribution: a case of medieval Staraya Ladoga skeletal sample [PDF]

Вестник археологии, антропологии и этнографии
The problem of estimating age-at-death structures using different methods is examined through the medieval skeletal sample from Staraya Ladoga. A comparative analysis of age estimates obtained using traditional age determination methods and a new method ...
Shirobokov I.G., Pavlova M.S.
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Kokel of Southern Siberia: New data on a post-Xiongnu material culture. [PDF]

PLoS One, 2021
Sadykov T, Caspari G, Blochin J, Lösch S, Kapinus Y, Milella M.   +5 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Genetics and Material Culture Support Repeated Expansions into Paleolithic Eurasia from a Population Hub Out of Africa. [PDF]

Genome Biol Evol, 2022
Vallini L, Marciani G, Aneli S, Bortolini E, Benazzi S, Pievani T, Pagani L.   +6 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Исследование «пещерного города» Эски-Кермен в 20-е — 30-е годы XX века / The research of the Eski-Kermen “cave town” in the 20's and 30's of the 20th century

Материалы по археологии и истории античного и средневекового Крыма, 2016
Целью исследования стало освещение малоизученных моментов истории изучения «пещерного города» Эски-Кермен. В предлагаемой вашему вниманию статье пойдет речь об исследовании этого памятника истории и культуры, проведенного экспедицией ГАИМК, а также ...
N.A. Abramova
doaj