Results 101 to 110 of about 10,287,445 (293)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Single-Artifact Approach to Material Culture Studies: A Perspective from New Zealand

, 2011
In this chapter I present an approach to material culture studies, from the perspective of a Pakeha/European New Zealander, which draws upon my knowledge and understanding of nga rakau korero, the talking sticks of the indigenous Maori people of New ...
Smith, J
core  

Review of the research programme on the Mortella III wreck (2010-2020, Corsica, France): A contribution to the knowledge of the Mediterranean naval architecture and material culture of the Renaissance. [PDF]

Open Res Eur, 2022
Cazenave de la Roche A, Ciacchella F, Langenegger F, Guérout M, Milanese M, Crespo Solana A.   +5 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Thinking through the obscene: On Noam Yuran’s The Sexual Economy of Capitalism

Finance and Society
The Sexual Economy of Capitalism is a unique, illuminating, and deeply disturbing book. In this essay, I seek to show that Yuran’s key themes – sex and money – are chosen precisely for their obscene, transgressive nature, and that this choice is of ...
Yuval Kremnitzer
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

To the Definition of Technological Contexts Completeness of in Stone Industry from Cultural Layer 3 of Late Paleolithic Site Strelka-1 in Krasnoyarsk (On the Example of Side Scrapers)

Вестник Новосибирского государственного университета. Серия: история, филология
Purpose. The Strelka-1 site is located in the historical center of Krasnoyarsk where the Kacha River flows into the Yenisei River. Cultural layer 3 of the site dates back to the Upper Paleolithic period and contains numerous items made of stone and ...
A. V. Kolesnik, E. Yu. Girya, A. V. Barkov, E. V. Artemiev   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

THE EARLIEST EVIDENCE OF THE MANUFACTURING OF SOLUTIONS AND VISCOPLASTIC MIXTURES FROM PAINT PIGMENTS ON THE RUSSIAN PLAIN IN THE MIDDLE PALEOLITHIC

Нижневолжский археологический вестник
The article presents the results of studying a series of small individual pigment particles discovered in the cultural layer of the Chelyuskinets II site, which is part of the Lower Volga Middle Paleolithic group together with the Eurasian ...
Maria Zheltova, Maria Komagorova, Yulia Anisovets, Vladislav Zhitenev, Darya Ulyanova, Redzhep Kurbanov, Ksenia Stepanova, Anton Anoykin, Yaroslav Ivanov, Vasilisa Smolkina, Evgeniy Kazakov, Stanislav Remizov, Aleksander Otcherednoy   +12 more
doaj   +1 more source