Results 91 to 100 of about 9,042,160 (311)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
The United Nations Basic Space Science Initiative: The TRIPOD concept [PDF]
, 2006 Since 1990, the United Nations is annually holding a workshop on basic space science for the benefit of the worldwide development of astronomy. Additional to the scientific benefits of the workshops and the strengthening of international cooperation, the
A.M. Mathai +15 more
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
LSA silicon material task closed-cycle process development [PDF]
The initial effort on feasibility of the closed cycle process was begun with the design of the two major items of untested equipment, the silicon tetrachloride by product converter and the rotary drum reactor for deposition of silicon from ...
Blocher, J. M., Jr. +4 more
core +1 more source
Philosophy of Intellect in the Long Commentary on the De anima of Averroes [PDF]
, 2012 In the Long Commentary on the De anima, Averroes posits three separate intelligences in the anima rationalis or the rational soul: agent intellect or intellectus agens, material or passible intellect, intellectus possibilis or intellectus passibilis, and
Hendrix, John S
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
DEVELOPING ENGLISH COURSE BOOK FOR SECOND GRADE KINDERGARTENERS
Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2017 This study is aimed to develop English course-book for second grade of kindergarten. The method used in this study is Research and Development (R&D).
Lely Silia Wardhani +2 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Development of a material processing plant for lunar soil [PDF]
Currently there is considerable interest in developing in-situ materials processing plants for both the Moon and Mars. Two of the most important aspects of developing such a materials processing plant is the overall system design and the integration of ...
Goettsch, Ulix, Ousterhout, Karl
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source