Results 131 to 140 of about 287,684 (305)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
[Review of] John Bodnar. The Transplanted: A History of Immigrants in Urban America [PDF]
, 1988 The Transplanted is represented as a synthesis of the immigrant experience in urban America. Bodnar posits the confrontation with capitalism as sole explanation for migration, emigration and immigrant behavior in the new country. His stated intent is to
Eive, Gloria
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
[Review of] Marion Wilson Starling. The Slave Narrative: Its Place in American History [PDF]
, 1990 This is another reprint of Marion Wilson Starling\u27s breakthrough study of the slave narrative, which she undertook for her Ph.D. dissertation at New York University in 1946 under the advisorship of Oscar Cargill.
Costanzo, Angelo
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Deployable Gridshells and their application as a Physical Form Finding Tool: Constructing an innovative life-size Strained Timber Gridshell [PDF]
, 2012 This paper presents and discusses the outcomes of a recent participatory workshop where timber gridshells were designed and constructed intuitively by architecture students using physical models.
Tang, Gabriel
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
A Material Strategy : Exploring Material Properties of Computers
, 2010 As design problems are inherently indeterminate or wicked, we have to rely on various strategies when practicing design. In this paper, we propose a material strategy that emphasizes the expressional potential of computers. We argue how computers, in principle, can be understood as a material for design and how they can be part of a formgiving practice.
Vallgårda, Anna, Sokoler, Tomas
openaire +1 more source