Results 91 to 100 of about 226,002 (291)
A Modern Framework for Measuring Poverty and Basic Economic Security [PDF]
, 2010 This report details how the dominant framework for understanding and measuring poverty in the United States has become a conservative one. The current U.S.
Shawn Fremstad
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Understanding Persistent Food Insecurity: A Paradox of Place and Circumstance [PDF]
Survey data from a USDA-funded multi-state longitudinal project revealed a paradox where rural low-income families from states considered prosperous were persistently more food insecure than similar families from less prosperous states. An examination of
Jean W. Bauer +2 more
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The effect of early childhood material hardship mitigation on adolescent success
Future Healthcare JournalIntroduction: Academic outcomes are reduced in children and adolescents from low-income families compared with their wealthier peers. Income stratification corresponds with education outcomes.
Bria McKenzie, Frances Shofer
doaj +1 more source
Low-Income Mothers’ Material Hardship and Children’s Socioemotional WellBeing [PDF]
Research suggests that children from low-income families are more likely to exhibit behavioral problems than children from wealthier families and these adverse behaviors have long-term detrimental effects on academic outcomes, health and earnings.
Afshin Zilanawala, Natasha V. Pilkauskas
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Reasonable Accommodation Under the ADA [PDF]
, 2011 This brochure is one of a series on human resources practices and workplace accommodations for persons with disabilities edited by Susanne M. Bruyère, Ph.D., CRC, SPHR, Director, Program on Employment and Disability, School of Industrial and Labor ...
Bruyere, Susanne M +3 more
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Beyond nudging: it’s time for a second generation of behaviourally-informed social policy [PDF]
, 2016 Insights from experimental research in the behavioural sciences offer a powerful impetus to reject punitive welfare reform. Katherine Curchin explains that findings from psychology, behavioural economics and behavioural finance concerning decision-making
Curchin, Katherine
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Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source