Results 71 to 80 of about 226,002 (291)
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Disagreement in Partners’ Reports of Financial Difficulty [PDF]
We use unique data in which both partners report about household finances to demonstrate that there is often disagreement about whether the household has experienced financial difficulty in the past year.
Danielle Venn +3 more
core +3 more sources
Persistent material hardship and childhood physical aggression
Aggression and Violent Behavior, 2019 Abstract Some developmental models of childhood aggression deny any influence of socioeconomic status (SES), while others stress a more central role. We argue that greater attention to persistent material hardship (i.e., inability to provide for basic needs) may enhance the centrality of SES in developmental approaches.
Bellair, PE, McNulty, TL, Piquero, AR
openaire +2 more sources
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Discovery From Non-Parties (Third-Party Discovery) in International Arbitration [PDF]
, 2010 International arbitration rules and many arbitration laws usually provide procedures that permit tribunals to order parties to disclose documents and other materials to the other parties.1 More complex are the rules that determine opportunities to obtain
Verrill, Charles O., Jr.
core +4 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
The living standards of families with children reporting low incomes [PDF]
, 2009 The Government has high-profile child poverty targets which are assessed using a measure of income, as recorded in the Household Below Average Income series (HBAI). However, income is an imperfect measure of living standards.
Brewer, M. +3 more
core
The challenge of securing durable reductions in child poverty in New Zealand [PDF]
, 2013 This article examines the causes of child poverty in New Zealand and how child poverty rates might be reduced.New Zealand has tolerated significant levels of relative child poverty for more than two decades.
Jonathan Boston
core +2 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Palliative Care and Social Practice, 2023 Background: International palliative care policy often views home as the most desirable location for end-of-life care. However, people living in more deprived areas can worry about dying in poor material circumstances and report more benefits from ...
Sam Quinn, Naomi Richards, Merryn Gott
doaj +1 more source