Results 81 to 90 of about 226,002 (291)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Trauma Surgery & Acute Care OpenMany patients experience financial hardship after acute injuries or emergency surgery. Financial hardship, often referred to as “financial toxicity,” comprises material hardship due to unexpected bills and income loss, psychosocial stress due to ...
Marie L Crandall +13 more
doaj +1 more source
Cancer Medicine, 2023 Background Basic resource needs related to transportation, housing, food, and medications are important social determinants of health and modifiable indicators of poverty, but their role in modifying the risk of frailty and health‐related quality of life
Grant R. Williams +10 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Income, Material Hardship, and the Use of Public Programs among the Elderly [PDF]
I use data from the 2006 Health and Retirement Study to analyze the determinants of material hardship among individuals ages 65 and older. Ten percent of the elderly report hardship – defined here as cutting back on food or medications because of cost ...
Helen Levy
core
(Inter)Active Interviewing in Childhood Research: On Children\u27s Identity Work in Interviews [PDF]
, 2010 Seeing identity as work produced in interaction is a starting point in this current study, were analyzing interviews with children living in economic hardship, and how everyday life in economic hardship in one way or another becomes significant for their
Fernqvist, Stina
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
The Great Recession and Material Hardship [PDF]
Little research looks at the relationship between macroeconomic indicators and material hardship. High unemployment rates as a result of economic downturns are likely to lead to lost income, increased poverty, and material hardship. We examine the effect
Irwin Garfinkel +2 more
core
The lived experiences of food insecurity within the context of poverty in Hamilton, New Zealand : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Psychology at Massey University, Albany, New Zealand [PDF]
, 2017 Aotearoa/New Zealand is seeing increasing levels of hardship amongst the citizenry. Such developments can be traced to the implementation of neoliberal-based policies and the retrenchment of state-sponsored welfare and associated social safety nets. Food
Graham, Rebekah
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source