Results 101 to 110 of about 2,019,496 (342)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Science and Engineering of Composite Materials, 2011 In this study, non-linear static analysis of a cantilever Timoshenko beam composed of functionally graded material (FGM) under a non-follower transversal uniformly distributed load is studied with large displacements and large rotations.
Kocatürk Turgut +2 more
doaj +1 more source
Lattice Boltzmann Solution of Concave Longitudinal Fins under Step-changing base Boundary Conditions Associated with Accumulated Nonlinearity [PDF]
Journal of Applied and Computational MechanicsThis article reports the transient numerical solution of concave profile longitudinal fins under two cases of step-changing base boundary conditions involving heat flux and temperature, respectively.
Abhishek Sahu, Shubhankar Bhowmick
doaj +1 more source
Kinetic Inductance Magnetometer
, 2014 Ultrasensitive magnetic field detection is utilized in the fields of science, medicine and industry. We report on a novel magnetometer relying on the kinetic inductance of superconducting material.
Grönberg, Leif +3 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
High frequency electro-optic measurement of strained silicon racetrack resonators
, 2015 The observation of the electro-optic effect in strained silicon waveguides has been considered as a direct manifestation of an induced $\chi^{(2)}$ non-linearity in the material.
Bernard, M. +7 more
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
SoftwareXNew structural technologies are constantly being developed, especially in the case of high-impact loads, which cause significant demands on the structure's resistance to collapse.
Ana Waldila de Queiroz Ramiro Reis +2 more
doaj +1 more source