Results 51 to 60 of about 1,658,555 (265)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Tunable dual-band perfect absorber consisting of periodic cross-cross monolayer graphene arrays

Results in Physics, 2019
In this paper, we propose a tunable dual-band perfect absorber, which makes the thicker SiO2 dielectric as a spacer to separate the gold layer from the periodic cross-cross monolayer graphene array layer which locates the roof of whole absorber.
Zao Yi, Lin Liu, Lei Wang, Chunlian Cen, Xifang Chen, Zigang Zhou, Xin Ye, Yong Yi, Yongjian Tang, Yougen Yi, Pinghui Wu   +10 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Wear Performance of Metal Materials Fabricated by Powder Bed Fusion: A Literature Review

Metals, 2020
Powder Bed Fusion (PBF) is an additive manufacturing technology used to produce metal-based materials. PBF materials have a unique microstructure as a result from repeated and sharp heating/cooling cycles.
Hongling Qin, Runzhou Xu, Pixiang Lan, Jian Wang, Wenlong Lu   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Synthesis and Selected Properties of Ester Elastomer Containing Sorbitol

Applied Sciences, 2020
The aim of this work was synthesizing ester elastomers, using sorbitol as a monomer obtainable from renewable sources. Three polymers were synthesized, utilizing three different polycondensation times.
Marta Piątek-Hnat, Kuba Bomba, Jakub Pęksiński   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Experimental investigation of seashell concrete with anti-corrosion agent enhancement [PDF]

MATEC Web of Conferences
This research investigates the performance of seashell concrete enhanced with anti-corrosion agents, focusing on sustainability and durability. The study evaluates workability, density, compressive strength, modulus of elasticity, and corrosion ...
Abbas Ali, Abdalla Khalid, Saji Gopika
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source