Results 181 to 190 of about 5,332,166 (340)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Morphology and Comparative Transcriptome Analysis of Resistant and Susceptible Bitter Gourd (<i>Momordica charantia</i> L.) Reveals the Molecular Response Related to Powdery Mildew Resistance. [PDF]

J Fungi (Basel)
Xia L, Wang K, Guan F, Shi B, Yang X, Xie Y, Wan X, Zhang J.   +7 more
europepmc   +1 more source

The Influence of Wab-Based Powtoon Application Media on Social Science Learning Results for Grade 4 Cultural Diversity Material

Abdullohil Fashih, Vanda Rezania
openalex   +1 more source

The Materials Science of Semiconductors

, 2008

openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Materials dataset from microgravity levitation experiments on the China Space Station. [PDF]

Sci Data
Liu Y, Li S, Yang B, Liu Y, Deng Y, Yu J, Li X.   +6 more
europepmc   +1 more source

Materials for "Investigating the replicability of the social and behavioral sciences"

Brian A. Nosek, Timothy M. Errington, Andrew H. Tyner, Lesley Markham, Noah Haber, Theresa Stankov, Longze Chen   +6 more
openalex   +2 more sources

Application of digital technologies in higher education in “Materials Science” for transport complex

, 2020
О. В. Чудина
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

RETRACTED: Tarawneh et al. Berberine Inhibited Growth and Migration of Human Colon Cancer Cell Lines by Increasing Phosphatase and Tensin and Inhibiting Aquaporins 1, 3 and 5 Expressions. <i>Molecules</i> 2023, <i>28</i>, 3823. [PDF]

Molecules
Tarawneh N, Hamadneh L, Abu-Irmaileh B, Shraideh Z, Bustanji Y, Abdalla S.   +5 more
europepmc   +1 more source