Results 121 to 130 of about 10,525,256 (347)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Materiales moleculares. Aplicaciones en narices y lenguas electrónicas [PDF]
Presentaciones de la Decimotercera Jornada de Materiales de la Universidad Carlos III de Madrid celebrada el 31 de marzo de 2011 en Leganés, MadridNo ...
Rodríguez Méndez, María Luz
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El diseño interpreta la innovación en materiales
Este estudio ilustra los resultados de las experimentaciones proyectuales realizadas en el ámbito del proyecto Design for Science, nacido en el 2008 como fruto de la colaboración entre el grupo de investigación de diseño bioinspirado HDL (Hybrid Design ...
Carla Langella
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Viscoelastic models in green composites from PLA and hazelnut shell fillers with a natural plasticizer from epoxidized linseed oil [PDF]
[EN] In a same way to polymeric materials, some composite materials as it is the case of green composites, are characterized by a viscoelastic behaviour which plays a key role in their mechanical properties with time.
Balart, Javier-Francisco +9 more
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Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Innovar o domesticar. Proyectos entre humanos, animales, plantas y máquinas
Todos los animales sobrevivieron al tsunami que afectó a Tailandia en 2004, excepto aquellos que fueron domesticados. Si asociamos innovación con el término “de nuo” o “crescere” así como con “novus” o “creare” para producir avances en la humanidad, el ...
Cristina Jorge Camacho
doaj +1 more source
Biophysical approaches for studying viral entry
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Nuevos materiales de construcción ecosostenibles por su acción superhidrofugante [PDF]
La protección de materiales de construcción frente a la acción del agua, el principal vehículo de los agentes de degradación, es un factor clave para aumentar la vida útil de los edificios.
Martínez Carrascosa, Luis Antonio
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