Results 171 to 180 of about 400,850 (345)

Algorithmic emergence? Epistemic in/justice in AI-directed transformations of healthcare

open access: yesFrontiers in Sociology
Moves toward integration of Artificial Intelligence (AI), particularly deep learning and generative AI-based technologies, into the domains of healthcare and public health have recently intensified, with a growing body of literature tackling the ethico ...
Imo Emah, SJ Bennett
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Silence as an element producer of moods/atmospheres in the film Rififi, by Jules Dassin

open access: yesTravessias, 2018
In this paper, I reflect on the presence of silence in Jules Dassin's film Rififi (Du rififi chez les hommes, 1955), more specifically in the long scene of heist.
Diogo Rossi Ambiel Facini
doaj  

Between energy transition and industrial revival: Exploring hydrogen imaginaries in the United Kingdom and Teesside

open access: yesGeo: Geography and Environment
Hydrogen is increasingly positioned as a key enabler of global net‐zero transitions, hailed for its versatility and low‐carbon emissions potential.
Naima Kraushaar‐Friesen   +2 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

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