Results 111 to 120 of about 1,702,166 (311)

Spark plasma effect on microstructure and mechanical properties of alumina-nickel-cobalt composite

Cerâmica
Spark plasma sintering (SPS) is an advanced process of sintering materials at low temperatures and short time by creating spark plasma at very high temperatures in the small points and short times, by which materials with high sintering temperature can ...
J. Baseri, R. Naghizadeh, H. R. Rezaie, F. Golestanifard   +3 more
doaj   +1 more source

High temperature dielectric properties of Apical, Kapton, Peek, Teflon AF, and Upilex polymers [PDF]

Reliable lightweight systems capable of providing electrical power at the magawatt level are a requirement for future manned space exploration missions.
Baumann, E. D., Hammoud, A. N., Khachen, W., Laghari, J. R., Myers, I. T., Overton, E., Suthar, J. L.   +6 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Evidence of a temperature transition for denuded zone formation in nanocrystalline Fe under He irradiation

Materials Research Letters, 2017
Nanocrystalline materials are radiation-tolerant materials’ candidates due to their high defect sink density. Here, nanocrystalline iron films were irradiated with 10 keV helium ions in situ in a transmission electron microscope at elevated temperatures.
O. El-Atwani, J. E. Nathaniel, A. C. Leff, J. K. Baldwin, K. Hattar, M. L. Taheri   +5 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Ultrahigh Pressure Generation at High Temperatures in a Walker-Type Large-Volume Press and Multiple Applications

Engineering
Ultrahigh pressure generation at high temperatures is technologically challenging for large sample volumes. In this study, we successfully generated pressures of 37.3–40.4 GPa at 1900–2100 K in a Walker-type large-volume press (LVP).
Xuyuan Hou, Yuchen Shang, Luyao Chen, Bingtao Feng, Yuanlong Zhao, Xinyu Zhao, Kuo Hu, Qiang Tao, Pinwen Zhu, Zhihui Li, Ran Liu, Zhaodong Liu, Mingguang Yao, Bingbing Liu   +13 more
doaj   +1 more source

Rapid-Rate Compression Testing of Sheet Materials at High Temperatures [PDF]

This Report describes the test equipment that was developed and the procedures that were used to evaluate structural sheet-material compression properties at preselected constant strain rates and/or loads. Electrical self-resistance was used to achieve a
Bernett, E. C., Gerberich, W. W.
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Composite materials at high temperatures

, 1988
An experimental investigation was made to determine the ultimate tensile strength and elastic modulus of IM6-3501-6 graphite epoxy laminated specimens exposed to temperatures from 70°F to 600°F. Specimens were layered (0°), (90", 0"), (90 ° , 0° , 90° ) . The coupons used are candidate materials for advanced tactical missile airframe design. A Material
openaire   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source