Results 171 to 180 of about 15,809,998 (339)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Retracted: Photocatalyst and Decoration Design in Indoor Public Spaces Based on the Photocatalytic Function of Nanometer Titanium Dioxide

Advances in Materials Science and Engineering, 2023
Advances in Materials Science and Engineering
doaj   +1 more source

Sustainable valorization of Alpinia galanga pseudostem fibers for characterization and materials engineering applications. [PDF]

Sci Rep
Babu SS, Jiyas N, Sasidharan I, Kumar KB, Thomas VP, Thomas BT, Dan M.   +6 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Retracted: Using Convolutional Neural Networks for Segmentation of Multiple Sclerosis Lesions in 3D Magnetic Resonance Imaging

Advances in Materials Science and Engineering, 2023
Advances in Materials Science and Engineering
doaj   +1 more source

Modulating Microbial Materials - Engineering Bacterial Cellulose with Synthetic Biology. [PDF]

ACS Synth Biol
Malcı K, Li IS, Kisseroudis N, Ellis T.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Retracted: The Application of Nano-Calcium Carbonate in the Technology of Improving Road Petroleum Asphalt

Advances in Materials Science and Engineering, 2023
Advances in Materials Science and Engineering
doaj   +1 more source

Materials engineering by ameloblasts. [PDF]

J Dent Res, 2015
Habelitz S.
europepmc   +1 more source

Engineering Materials [PDF]

, 1990
openaire   +1 more source