Results 61 to 70 of about 343,528 (265)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The crystal structure of poly[(μ 2-2-aminoisophthalato-κ4O,O′:O″:O″′)-(N-methylpyrrolidone κ1O)-dioxido-uranium(VI)], C13H14N2O7U

Zeitschrift für Kristallographie - New Crystal Structures
C13H14N2O7U, monoclinic, P21/n (no. 14), a = 8.6855(14) Å, b = 11.982(2) Å, c = 14.953(2) Å, β = 94.557(5)°, V = 1,551.3(4) Å3, Z = 4, R gt(F) = 0.0559, wR ref (F 2) = 0.1081, T = 150(2 ...
Meng Yuning, Liu Ruan-Xiang, Bao Han, Jin Ru-Yu, Song Shi-He, Feng Gui-Jiao   +5 more
doaj   +1 more source

Insights into the corrosion resistance of Cr-Mo alloy reinforcing steel in simulated pore solution and real seawater sea-sand concrete: A preliminary study

Case Studies in Construction Materials
Corrosion of steel bars embedded in reinforced concrete structures considerably reduces the service life and even causes early failure of the structure.
Zhongyi Xin, Le Guo, Fengjuan Wang, Qi Luo, Liguo Wang, Huande Chen, Zhiyong Liu, Jinyang Jiang   +7 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Author Correction: Multi-layered cement-hydrogel composite with high toughness, low thermal conductivity, and self-healing capability

Nature Communications, 2023
Yuan Chen, Yangzezhi Zheng, Yang Zhou, Wei Zhang, Weihuan Li, Wei She, Jiaping Liu, Changwen Miao   +7 more
doaj   +1 more source

Solvothermal synthesis and crystal structure of poly((μ3-2-amino-1,3-benzenedicarboxylato-κ4O:O′,O″,O‴)-bis(μ4-2-amino-1,3-benzenedicarboxylato-κ5O:O:O′,O″,O‴)-(N,N-dimethylformamide)-aqua-di-europium(III)-N,N-dimethylformamide solvate, C30H31N5O7Eu2

Zeitschrift für Kristallographie - New Crystal Structures
C30H31N5O7Eu2, orthorhombic, Pna21 (no. 34), a = 18.1766(8) Å, b = 11.0796(5) Å, c = 16.5109(6) Å, V = 3325.1(2) Å3, Z = 4, Rgt(F) = 0.0230, wRref(F2) = 0.0611, T = 150(2) K.
Liu Ruan-Xiang, Jin Ru-Yu, Chen Xing-Yu, Song Shi-He, Cai Bin, Meng Yuning   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Quantitative solution on dosage of repair agent for healing of cracks in materials: short capsule model vs. two-dimensional crack pattern

Science and Engineering of Composite Materials, 2011
Cracks are vitally detrimental to the load-bearing capacity of materials and further to the durability and service-life of various structures. Crack-repairing technology via embedded capsules with repair agent is becoming a promising approach to sustain ...
Lv Zhong, Chen Huisu, Yuan Haifeng
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source