Results 21 to 30 of about 59,771 (215)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Position Paper: the Sustainability of Plastics
Chemical Engineering Transactions, 2023 The unique properties and performance of plastic materials entail their massive production and use with consequently generation of huge amount of plastic waste, which can cause significant impact on the environment, if not properly managed. Institutional
Daniele Antonini +8 more
doaj
Plastics in the US: toward a material flow characterization of production, markets and end of life
Environmental Research Letters, 2020 Managing plastics has become a focal issue of the Anthropocene. Developments in plastic materials have made possible many of the technologies and conveniences that define our modern life.
Martin C Heller +2 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Biodegradation of plastics at home composting conditions
Environmental Challenges, 2022 Plastics have become an ever-increasing environmental pollution problem since high amounts of them are dumped every year into the environment. To remediate this problem, many proposals attempt to produce new plastics with the same sound characteristics ...
Godofredo Solano +4 more
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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Computational Rheology with Integral Constitutive Equations
Applied Rheology, 1999 Computational rheology deals with the formulation and solution of constitutive equations for non-Newtonian materials. From these the emphasis is put on polymeric materials, which exhibit both viscous and elastic behaviour in flow and deformation.
Mitsoulis Evan
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Fabrication and Biodegradability of Starch Cell-Plastics as Recyclable Resources
Applied Sciences, 2021 Recently, cell-plastics, which are composed of unicellular green algal cells and biodegradable compounds as ingredients and fillers, have been suggested as carbon-recyclable materials instead of petroleum-based plastics.
Akihito Nakanishi +7 more
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Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
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