Results 31 to 40 of about 4,974,460 (256)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Computational Rheology with Integral Constitutive Equations
Applied Rheology, 1999 Computational rheology deals with the formulation and solution of constitutive equations for non-Newtonian materials. From these the emphasis is put on polymeric materials, which exhibit both viscous and elastic behaviour in flow and deformation.
Mitsoulis Evan
doaj +1 more source
Fabrication and Biodegradability of Starch Cell-Plastics as Recyclable Resources
Applied Sciences, 2021 Recently, cell-plastics, which are composed of unicellular green algal cells and biodegradable compounds as ingredients and fillers, have been suggested as carbon-recyclable materials instead of petroleum-based plastics.
Akihito Nakanishi +7 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Living plastics from plasticizer-assisted thermal molding of silk protein
Nature CommunicationsThe pursuit of materials, particularly plastics, with a minimal ecological footprint throughout their circular lifecycle, is crucial for advancing sustainable materials development.
Yushu Wang +12 more
doaj +1 more source
Biodegradable materials in dentistry: A comprehensive review of current trends [PDF]
The dental industry has witnessed a paradigm shift towards biodegradable materials, driven by the need for sustainable and environmentally friendly solutions.
Kambala, Meena Lakshmi Reddy +3 more
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
ESTRUCTURA I PROPIETATS DELS MATERIALS PLÀSTICS (2n examen parcial)
, 2010 Examen d'Estructura i propietats dels materials ...
Antunes, Marcelo de Sousa Pais
core +1 more source