Results 31 to 40 of about 56,551 (221)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Living plastics from plasticizer-assisted thermal molding of silk protein
Nature CommunicationsThe pursuit of materials, particularly plastics, with a minimal ecological footprint throughout their circular lifecycle, is crucial for advancing sustainable materials development.
Yushu Wang +12 more
doaj +1 more source
Review of recycling waste plastics in asphalt paving materials
Journal of Traffic and Transportation Engineering (English ed. Online), 2022 An ever-growing demand for depleted natural resources is one of the significant challenges facing the global asphalt pavement industry in building and maintaining global asphalt pavements.
Lingyun You +7 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
EcoMat, 2023 Over the past three decades, significant efforts have been dedicated to developing polymeric materials with exciting healable ability; however, stiff and healable plastics with high glass transition temperatures (Tg) have received relatively less ...
Tong Liu +3 more
doaj +1 more source
Plastic Skinscapes in Tibetan Buddhism
The Copenhagen Journal of Asian Studies, 2022 This article takes as its point of departure S. Brent Plate's (2012) compelling metaphor ‘the skin of religion’ to discuss the increasing presence and impact of plastics in the sphere of religion.
Trine Brox
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
ChallengesFood contact materials release bioactive molecules that are potentially detrimental to health. Despite the relevance of this daily and repeated exposure, little attention is paid to single-use materials in contact with food.
Aristide Guillaume Silapeux Kamda +8 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source