Results 31 to 40 of about 60,349 (215)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Living plastics from plasticizer-assisted thermal molding of silk protein

Nature Communications
The pursuit of materials, particularly plastics, with a minimal ecological footprint throughout their circular lifecycle, is crucial for advancing sustainable materials development.
Yushu Wang, Junqi Wu, Emily J. Hartzell, Weiguo Hu, Reddhy Mahle, Xinxin Li, Ying Chen, Jugal Kishore Sahoo, Cameron Chan, Brooke N. Longo, Charlotte S. Jacobus, Chunmei Li, David L. Kaplan   +12 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Functional carbon materials from waste plastics: synthesis and applications

Sustainable Carbon Materials
The global accumulation of waste plastics has led to severe environmental pollution, posing a serious threat to ecosystems. Conventional disposal methods, such as landfilling, mechanical recycling, and incineration, remain limited by low conversion ...
Jin Yuan, Gaixiu Yang, Xiaoyue Zhou, Jianlin Huang, Yan Chen   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Review of recycling waste plastics in asphalt paving materials

Journal of Traffic and Transportation Engineering (English ed. Online), 2022
An ever-growing demand for depleted natural resources is one of the significant challenges facing the global asphalt pavement industry in building and maintaining global asphalt pavements.
Lingyun You, Zhengwu Long, Zhanping You, Dongdong Ge, Xu Yang, Fu Xu, Mohammad Hashemi, Aboelkasim Diab   +7 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

High‐performance healable plastics: Focusing topological structure design based on constitutional dynamic chemistry

EcoMat, 2023
Over the past three decades, significant efforts have been dedicated to developing polymeric materials with exciting healable ability; however, stiff and healable plastics with high glass transition temperatures (Tg) have received relatively less ...
Tong Liu, Lin Wang, JianHua Xu, JiaJun Fu   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Learning from Tradition: Consumer Attitudes and Perceptions of Leaf and Plastic Food Wrapping and Packaging in Kumba, Southwest Cameroon

Challenges
Food contact materials release bioactive molecules that are potentially detrimental to health. Despite the relevance of this daily and repeated exposure, little attention is paid to single-use materials in contact with food.
Aristide Guillaume Silapeux Kamda, Pricillia Anjeh, Gillian Asoba, Solange Nwobonche Chiakeh, Elizabeth Nebale, Francesca Baldi, Samuel Metugue, Fidelis Ebong, Chiara Frazzoli   +8 more
doaj   +1 more source