Results 21 to 30 of about 60,349 (215)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Position Paper: the Sustainability of Plastics
Chemical Engineering Transactions, 2023 The unique properties and performance of plastic materials entail their massive production and use with consequently generation of huge amount of plastic waste, which can cause significant impact on the environment, if not properly managed. Institutional
Daniele Antonini +8 more
doaj
Plastics in the US: toward a material flow characterization of production, markets and end of life
Environmental Research Letters, 2020 Managing plastics has become a focal issue of the Anthropocene. Developments in plastic materials have made possible many of the technologies and conveniences that define our modern life.
Martin C Heller +2 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Biodegradation of plastics at home composting conditions
Environmental Challenges, 2022 Plastics have become an ever-increasing environmental pollution problem since high amounts of them are dumped every year into the environment. To remediate this problem, many proposals attempt to produce new plastics with the same sound characteristics ...
Godofredo Solano +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Computational Rheology with Integral Constitutive Equations
Applied Rheology, 1999 Computational rheology deals with the formulation and solution of constitutive equations for non-Newtonian materials. From these the emphasis is put on polymeric materials, which exhibit both viscous and elastic behaviour in flow and deformation.
Mitsoulis Evan
doaj +1 more source
Fabrication and Biodegradability of Starch Cell-Plastics as Recyclable Resources
Applied Sciences, 2021 Recently, cell-plastics, which are composed of unicellular green algal cells and biodegradable compounds as ingredients and fillers, have been suggested as carbon-recyclable materials instead of petroleum-based plastics.
Akihito Nakanishi +7 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source