Results 91 to 100 of about 19,473,068 (392)
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
, 2008 The realm of biomaterials, under which biomedical materials can be categorised, has a broad definition base and recognises materials that are synthesized or naturally sourced.
Mucalo, Michael R., Worth, Andrew J.
core
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Knowledge of process-structure-property relationships to engineer better heat treatments for laser powder bed fusion additive manufactured Inconel 718 [PDF]
Additive Manufacturing, 2019 T. Gallmeyer +14 more
semanticscholar +1 more source
Materials science and engineering [PDF]
, 1993 During FY-96, work within the Materials Science and Engineering Thrust Area was focused on material modeling. Our motivation for this work is to develop the capability to study the structural response of materials as well as material processing. These capabilities have been applied to a broad range of problems, in support of many programs at Lawrence ...
openaire +5 more sources
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Retracted: Effect of Using Modern Banking Services on Customer Inspiration: Statistical Analysis
Advances in Materials Science and Engineering, 2023 Advances in Materials Science and Engineering
doaj +1 more source
Science led vs design led teaching approaches in materials science and engineering for aeronautical engineering students [PDF]
, 2013 A comparison on teaching styles has been conducted by analysing behavioural, cognitive, developmental, social cognitive and constructivist perspectives of 26 students (higher engineering apprentices).
Inam, Fawad
core
Looking for Design in Materials Design
, 2004 Despite great advances in computation, materials design is still science fiction. The construction of structure-property relations on the quantum scale will turn computational empiricism into true design.Comment: 3 pages, 1 ...
CS Smith +5 more
core +1 more source