Results 71 to 80 of about 7,704,491 (343)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Materiality between Art, Science, and Culture in the Viceroyalties (16^th–17^th Centuries): An Interdisciplinary Vision toward the Writing of a New Colonial Art History [PDF]

, 2017
Gabriela Siracusano, Agustina Rodrîguez Romero   +1 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Effects of STEM-based learning materials on knowledge and literacy of students in science and physics learning: a meta-analysis [PDF]

, 2022
Nurul Hikmah Annisa, Asrizal Asrizal, Festiyed Festiyed   +2 more
openalex   +1 more source

Science and Subpoenas: When do the Courts Become Instruments of Manipulation? [PDF]

, 1996
Fischer says he believes that the uneasy relationship between law and science is likely to continue regarding disclosure of scientific research ...
Fischer, Paul M.
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Designing Material Learning for 5th Grade Elementary School using Science, Technology, Engineering, and Mathematics (STEM)

, 2023
Tyas Heruprahoro, Subuh Anggoro, Ristiana Dyah Purwandari   +2 more
openalex   +2 more sources

Biomedicals from Bone [PDF]

, 2008
The realm of biomaterials, under which biomedical materials can be categorised, has a broad definition base and recognises materials that are synthesized or naturally sourced.
Mucalo, Michael R., Worth, Andrew J.
core  

Doping Dependence of the Chemical Potential in Cuprate High-$T_{\rm c}$ Superconductors I: La$_{2-x}$Sr$_x$CuO$_4$

, 1994
The names of the authors, which were inadvertedly lacking in the tex-file submitted two days ago, have been added.Comment: 10 pages, figures on request. Revtex, version 2, Materials Science Center Internal Report Number VSGD.94.6.
Allen, Anderson, Blank, Blank, Briggs, Burroughs, Chen, D. van der Marel, Eskes, Etemad, Fowler, Fuggle, G. Rietveld, Gao, Glastra, Gopinath, Gupta, Hass, Hidaka, Hill, Hillebrecht, Imer, Itti, Kao, King, Kusumoki, M. Glastra, Manzke, Mattheis, Moorjani, Nagarkar, Nücker, Olson, Panson, Payzant, Pickett, Riesterer, Rietveld, Schönhammer, Scofield, Shafer, Shen, Shen, Shen, Shirley, Steiner, Steiner, Suzuki, Suzuki, Tagaki, Tagaki, Takahashi, Takahashi, Torrance, Uchida, van Doveren, van Veenendaal, Viswanathan, Wagner, Welp, Yi, Young   +61 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source