Results 181 to 190 of about 5,516,430 (308)

Repository of all experimental research materials, data collected, and analytical scripts in Open Science Framework

Research materials and data will be produced and made available in Open Science Framework. Data will be collected by two online fieldwork companies (one for Spain and another one for Hungary) and analysed by UPF with the collaboration of CSS.
openaire   +1 more source

Sol-gel interconvertible 62-component dodecahedra assembled via amide-π-assisted anion-coordination nanoarchitectonics. [PDF]

Sci Adv
Fu WZ, Zhuo Z, Nan ZA, Wang W, Liu JR, Li Q, Liu LY, Chen T, Zhang YL, Tian ZQ, Li Z, Hong MC, Huang YG.   +12 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

3D mapping of defects and moiré corrugations via electron ptychography atomic coordinate retrieval. [PDF]

Sci Adv
Huang J, Zhang Y, Bae SH, Ahammed B, Ertekin E, Huang PY.   +5 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Observation of synthetic moving effect in metamaterials. [PDF]

Light Sci Appl
Yang Q, Li Z, Wen X, You O, Ishihara T, Yin X, Zhang S.   +6 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Towards efficient and accurate input for data-driven materials science from large-scale all-electron density functional theory (DFT) simulations

Science is and always has been based on data, but the terms 'data-centric' and the '4th paradigm' of materials research indicate a radical change in how information is retrieved, handled and research is performed. It signifies a transformative shift towards managing vast data collections, digital repositories, and innovative data analytics methods. The
Kokott, S., Marek, A., Merz, F., Karpov, P., Carbogno, C., Rossi, M. ; https://orcid.org/0000-0002-3552-0677, Rampp, M., Blum, V., Scheffler, M.   +8 more
openaire   +1 more source

Room-temperature spinor condensate in halide perovskite microcavity. [PDF]

Sci Adv
Inukai T, Shibano R, Ogura T, Inoue T, Okada D, Takahashi S, Yamashita K.   +6 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source