Results 201 to 210 of about 9,529,278 (349)

Towards efficient and accurate input for data-driven materials science from large-scale all-electron density functional theory (DFT) simulations

Science is and always has been based on data, but the terms 'data-centric' and the '4th paradigm' of materials research indicate a radical change in how information is retrieved, handled and research is performed. It signifies a transformative shift towards managing vast data collections, digital repositories, and innovative data analytics methods. The
Kokott, S., Marek, A., Merz, F., Karpov, P., Carbogno, C., Rossi, M. ; https://orcid.org/0000-0002-3552-0677, Rampp, M., Blum, V., Scheffler, M.   +8 more
openaire   +1 more source

Uptake and Binding of At-211 Into K- and Cs-Derivatives of Alpha-Zirconium Phosphate Nanoplatelets for Use as a Targeted Alpha Therapy Delivery Platform. [PDF]

Small Sci
Madhushan BDI, Orsi AL, Perera JS, Pyles JM, Lawrence CC, Le M, Tabacaru GC, Fritz SR, McIntosh LA, Yennello SJ, Burns JD.   +10 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Materials of the all-Russian scientific conference with international participation "III Baikal materials science forum" (9-15 July 2018, Ulan-Ude). Part 2 [PDF]

Materials of the all-Russian scientific conference with international participation "III Baikal materials science forum" (9-15 July 2018, Ulan-Ude). Part 2, 2018
openaire   +1 more source

Enhanced two-dimensional ferromagnetism in van der Waals β-UTe₃ monolayers. [PDF]

Sci Adv
Thomas SM, Llacsahuanga Allcca AE, Simeth W, Kengle CS, Riedel ZW, Orlandi F, Khalyavin D, Manuel P, Ronning F, Bauer ED, Thompson JD, Zhu JX, Scheie AO, Chen YP, Rosa PFS.   +14 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

(Li_0.4Co_0.2Ni_0.2Cu_0.2Zn_0.2)WO₄: A Novel High-Entropy Wolframite Ceramic with Tailored Microwave Dielectric Properties. [PDF]

Materials (Basel)
Sun Y, Zhou X, Feng G, Li B, Yang D, Zhou D, Han J, Wang Q, Yang Y.   +8 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Fracture and Fatigue in Metals and Alloys. [PDF]

Materials (Basel)
Li S, Wang Z.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source