Results 111 to 120 of about 23,598 (185)

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Novel Synthetic Opioids (NSOs) and Their Evolving Crisis: Utilising NPSfinder^® as a Real-Time Predictive Tool. [PDF]

Pharmaceuticals (Basel)
Deligianni E, Arillotta D, Vento A, Corkery JM, Papazisis G, Goulas A, Lione L, Schifano F.   +7 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

The role of hormonal markers in predicting reproductive lifespan in girls with Turner syndrome-a retrospective study. [PDF]

J Endocr Soc
van der Coelen S, Sas T, Richter-Unruh A, Braat D, Fleischer K, Nadesapillai S, IntHout J, van der Velden J.   +7 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Assessment of Potential Exposure to Pregnancy-Contraindicated Medications Among Women of Reproductive Age in Japan: A Retrospective Database Study. [PDF]

Pharmacy (Basel)
Ura H, Matsuoka N.
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Perspectives of program directors regarding candidate selection for the Saudi Board of Restorative Dentistry program. [PDF]

Front Med (Lausanne)
AlQahtani AR, Mirza MB, AlQahtani Y, Aldaijy MT, Almalki A, AlBader S, Alharthi R, Alkheledan L, AlShehri A.   +8 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Evaluating the Ability of Artificial Intelligence to Address Nuanced Cardiology Subspecialty Questions: ChatGPT and CathSAP. [PDF]

J Soc Cardiovasc Angiogr Interv
Nanda S, Abaza K, Kyaw PH, Frankel R, Sardar P, Parikh SA, Shyam T, Chatterjee S.   +7 more
europepmc   +1 more source