Results 141 to 150 of about 1,541,611 (266)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Cobalt–Silicon Material Libraries Derived from High Throughput Experimentation and Their Application in Lithium Batteries

ACS Omega
Sven Uhlenbruck, Sandra Lobe, Yoo Jung Sohn, Christian Dellen, Walter Sebastian Scheld, Dina Fattakhova-Rohlfing, Olivier Guillon   +6 more
doaj   +1 more source

Graphene-Inspired Mono-Elemental 2D Materials: Synthesis, Properties, and Potential Applications of Xenes. [PDF]

Adv Sci (Weinh)
Yang Y, Xiao Y, Zhang Q, Yan Y, Wu T, Pang CH.   +5 more
europepmc   +1 more source

Editorial: Design of Functional Nanostructured Polymer Materials: Synthesis, Characterization and Applications. [PDF]

Front Chem, 2022
Álvarez VA, Copello GJ, Fernández de Luis R, Molina AI, Lázaro-Martínez JM.   +4 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Advancements in MXene Hybrid Materials: Synthesis, Characterization, and Applications in Energy Storage Technologies. [PDF]

Precis Chem
Ahmad H, Buhari S, Dabas R, Kronu T, Sharma A, Tomar S, Chalana A.   +6 more
europepmc   +1 more source

Thermally cross-linkable fluorene-based hole transporting materials: synthesis, characterization, and application in perovskite solar cells. [PDF]

RSC Adv, 2023
Vaitukaityte D, Magomedov A, Rakstys K, Kwiatkowski S, Kamarauskas E, Jankauskas V, Rousseau J, Getautis V.   +7 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Resorbable Bone-Fixation Materials: Synthesis, Physical-Chemical and Biological Properties. [PDF]

Avicenna J Med Biotechnol
Muzaffarova B, Eranov S, Tillayev S.
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source