Results 101 to 110 of about 1,642,260 (307)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Enhancement of Microstructure, Tensile and Fatigue Performance of EN AW-1050 by Wire-Based Friction Stir Additive Manufacturing

open access: yesJournal of Manufacturing and Materials Processing
Additive manufacturing (AM) of aluminium by solid-state routes offers a promising pathway to overcome the limitations of fusion-based processes, such as porosity and hot cracking. This study investigates the potential of wire-based friction stir additive
Stefan Donaubauer   +3 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Investigation of the Thermo-Mechanical Modeling of the Manufacturing of Large-Scale Wire Arc Additive Manufacturing Components with an Outlook Towards Industrial Applications

open access: yesJournal of Manufacturing and Materials Processing
The simulation of additive manufacturing processes, such as Wire Arc Additive Manufacturing (WAAM), is becoming increasingly important to predict material and component properties in advance of the real-life manufacturing.
Tim Fritschle   +3 more
doaj   +1 more source

Scratching Test on Hard-brittle Materials under High Hydrostatic Pressure.

open access: bronze, 1999
Masahiko Yoshino   +3 more
openalex   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Covalently Fluorophore-Functionalized ZIF‑8 Colloidal Particles as a Sensing Platform for Endocrine-Disrupting Chemicals Such as Phthalates Plasticizers

open access: yesACS Omega, 2019
Ander Chapartegui-Arias   +6 more
doaj   +1 more source

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