Results 51 to 60 of about 26,336 (230)

FNDC5 deficiency alters placental development, maternal body weight, and fetal-placental growth in mice

Scientific Reports
Irisin, a secreted myokine cleaved from FNDC5, regulates energy homeostasis and vascular function, but its role in pregnancy remains poorly understood.
Pinki Nandi, Mavis Lee, Dennis K. Lee, Sascha Drewlo   +3 more
doaj   +1 more source

Integrated one‐pot CRISPR‐Cas detection: Addressing strategies and future prospects

Interdisciplinary Medicine, EarlyView.
Integrated one‐pot CRISPR‐Cas detection significantly simplifies workflows, reduces cross‐contamination risks, and shortens turnaround times, making it highly suitable for point‐of‐care testing (POCT) and resource‐limited settings. Key challenges include system compatibility issues between Cas proteins and isothermal amplification, limited multiplexing
Jian Zhou, Xuemei Ren, Yingjie Ren, Ruiping Wu, Ruiman Geng, Le Chen, Zhuo Li   +6 more
wiley   +1 more source

A preterm neonate with infantile liver failure syndrome 1 due to leucyl‐tRNA synthetase 1 gene (LARS1) mutations with a histopathologic phenotype of neonatal hemochromatosis

JPGN Reports, EarlyView.
Abstract We report a case of a premature, growth‐restricted female infant with feeding intolerance and coagulopathy, treated initially for sepsis, who progressed to neonatal acute liver failure and end‐stage hepatic encephalopathy after a prolonged hospitalization with extensive diagnostic evaluation, and was found by autopsy to have histopathologic ...
Adrienne Bruder, Naomi Laventhal, Raja Rabah, Jacqueline Meadow   +3 more
wiley   +1 more source

Is maternal SARS-CoV-2 infection in the first trimester associated with congenital heart defects?

Frontiers in Pediatrics
Emerging evidence suggests a potential link between maternal SARS-CoV-2 infection during early pregnancy and the development of congenital heart defects (CHD) in offspring.
Athina Samara, Athina Samara, Athina Samara, Conrado Milani Coutinho, Paul T. Heath, Asma Khalil, Asma Khalil, Asma Khalil   +7 more
doaj   +1 more source

Managing Skin Diseases During Pregnancy: Treatment Discontinuation, Concerns and Physician Counselling

JEADV Clinical Practice, EarlyView.
Physiological changes during pregnancy can trigger or worsen dermatological conditions, yet evidence‐based guidance for safe management remains limited. In a cross‐sectional survey of 273 pregnant women, 33.7% reported having a skin disease, and 56% experienced worsening of symptoms.
Frederikke Seeberg, Anne Sofie Frølunde, Mette Deleuran, Line Kolding, Christian Vestergaard   +4 more
wiley   +1 more source

A Retrospective Study on Neonatal Jaundice: Early Risk Stratification Value of DAT‐FAT Serological Profiles Confirmed by AET

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This retrospective study aimed to explore the value of DAT‐FAT serological profiles confirmed by AET in classifying neonatal jaundice, evaluating its severity, and guiding clinical management. A total of 915 jaundiced newborns (584 pathological, 331 physiological) admitted from July 2018 to August 2021 were included.
Tian‐Ge Wu, Yan‐Feng Zhang, Zhong‐Jun Shen, Yao Li, Ning Xu, Xiao‐Yi Liu, Li‐Yan Zhao, Ming‐Hao Shi   +7 more
wiley   +1 more source

Survival of an infant with massive fetomaternal hemorrhage with a neonatal hemoglobin concentration of 1.2 g/dL without evident neurodevelopmental sequelae

SAGE Open Medical Case Reports, 2020
Fetomaternal hemorrhage is referred to as the passage of fetal blood into the maternal circulation. Massive hemorrhage can cause severe fetal anemia, affecting fetal and neonatal outcomes.
Jun Miyahara, Hiroshi Sugiura, Shigeru Ohki   +2 more
doaj   +1 more source

Brain Clearance of Contrast Agent in Intravenous DCE‐MRI Is Measurable and Cannot Be Explained by Clearance Across the BBB Alone

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To determine the feasibility of measuring brain clearance of gadolinium contrast agent using standard intravenous DCE‐MRI acquisitions and evaluate the contribution of blood–brain barrier (BBB) and non‐BBB clearance routes. Methods Uptake and extended Tofts models were fit to DCE‐MRI data from people with Parkinson's disease, post ...
Martin Kozár, Ioana‐Emilia Mosneag, Sarah Al‐Bachari, Igor Chernyavsky, Geoff J. M. Parker, Hervé Boutin, Laura M. Parkes, Ingo Schiessl, Ben R. Dickie   +8 more
wiley   +1 more source

Placental Blood‐Flow Velocity Quantification From Diffusion MRI

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Altered placental capillary blood flow is closely linked to obstetric complications, yet quantifying capillary‐scale blood velocity remains challenging with existing imaging methods. This is partially because capillary networks form disordered microvascular beds at the voxel scale, rather than coherent, directional vessels.
ZhuangJian Yang, Diana Cruz De Oliveira, Leevi Kerkelä, Marco Palombo, Elizabeth Powell, Christopher S. Parker, Daniel Cromb, Lisa Story, Serena J. Counsell, Kelly Payette, Joseph V. Hajnal, Jana Hutter, Rebecca J. Shipley, Daniel C. Alexander, Paddy J. Slator   +14 more
wiley   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source