Results 81 to 90 of about 65,040 (288)

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Placental Morphology Is Associated with Maternal Depressive Symptoms during Pregnancy and Toddler Psychiatric Problems. [PDF]

, 2018
Maternal depressive symptoms during pregnancy predict increased psychiatric problems in children. The underlying biological mechanisms remain unclear.
Cudmore, Melissa, Frank, Hans-Georg, Haeussner, Eva, Hämäläinen, Esa, Kajantie, Eero, Lahti-Pulkkinen, Marius, Laivuori, Hannele, Mehtälä, Susanna, Pesonen, Anu-Katriina, Reynolds, Rebecca M., Räikkönen, Katri, Schmitz, Christoph, Villa, Pia Maria   +12 more
core   +6 more sources

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Placentation in the paca (Agouti paca L)

Reproductive Biology and Endocrinology, 2005
Background The paca is a South American rodent with potential as a commercial food animal. We examined paca placenta as part of a wider effort to understand the reproductive biology of this species.
de Lima Marcelo, De Oliveira Moacir F, Machado Marcia, Carter Anthony M, Bonatelli Marina, Miglino Maria   +5 more
doaj   +1 more source

Exome Sequencing in Prenatally Diagnosed Isolated Neural Tube Defects: A Subtype‐Specific Analysis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To explore potential genetic contributors across different subtypes of isolated neural tube defects (NTDs) ‐ acrania–exencephaly–anencephaly sequence (AEAS), spinal dysraphism, and encephalocele ‐ using exome sequencing (ES) in a prenatal cohort, with the goal of gaining insight into the molecular diversity underlying these distinct ...
Adi Botvinik, Vered Offen Glasner, Adi Reches, Hadas Miremberg, Karina Krajden Haratz, Tal brill, Liron Malki, Michal Rozenzwaig, Yuval Yaron, Michal Levy   +9 more
wiley   +1 more source

Sex and fetal genome influence gene expression in pig endometrium at the end of gestation

BMC Genomics
Background A fine balance of feto-maternal resource allocation is required to support pregnancy, which depends on interactions between maternal and fetal genetic potential, maternal nutrition and environment, endometrial and placental functions.
Agnes Bonnet, Lisa Bluy, Laure Gress, Laurianne Canario, Laure Ravon, Aurelie Sécula, Yvon Billon, Laurence Liaubet   +7 more
doaj   +1 more source

Maternal-Fetal Endocrine Interface: A Systematic Review of the Clinicopathological Assessment of Hypothalamic-Pituitary-Adrenal Axis Dysregulation in Pregnancy Complications

Pakistan Journal of Medicine and Dentistry
Background: The hypothalamic-pituitary-adrenal (HPA) axis played a critical role in balancing maternal stress responses during pregnancy. This systematic review aimed to evaluate the dysregulation of the HPA axis and its link to pregnancy complications.
Fatima Bibi, Ome Kulsoom, Maria Khalid, Shama Chaudhry, Rehana Yasmeen, Shazia Sultana, Aneesa Khalid   +6 more
doaj   +1 more source

Vascular Growth in the Fetal Lung [PDF]

, 2011
The structure of the lung is truly remarkable. It is primarily composed of three branched tubular networks (the airway, pulmonary artery and vein, bronchial artery and vein) which supply blood and air to the site of gas exchange and which maintain ...
Land, Stephen
core   +4 more sources

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Second-Stage Labor Care: Challenges in Spontaneous Bearing Down [PDF]

, 2009
Substantial scientific evidence supports spontaneous maternal bearing down for its associated maternal and fetal physiologic benefits. Imposing specific directions for Valsalva pushing does not result in optimal outcomes but continues to be widely used ...
Hanson, Lisa
core   +1 more source