The long-term effects of maternal deprivation on the number and size of inhibitory interneurons in the rat amygdala and nucleus accumbens [PDF]
Frontiers in Neuroscience, 2023 IntroductionThere is an increasing evidence supporting the hypothesis that traumatic experiences during early developmental periods might be associated with psychopathology later in life.
Dubravka Aleksic +9 more
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The impact of early life maternal deprivation on the perineuronal nets in the prefrontal cortex and hippocampus of young adult rats [PDF]
Frontiers in Cell and Developmental Biology, 2022 Early life stress negatively impacts brain development and affects structure and function of parvalbumin immunopositive (PV+) inhibitory neurons. Main regulators of PV+ interneurons activity and plasticity are perineuronal nets (PNNs), an extracellular ...
Ana Jakovljevic +8 more
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Neurobiological mechanisms involved in maternal deprivation-induced behaviours relevant to psychiatric disorders [PDF]
Frontiers in Molecular Neuroscience, 2023 Parental care is essential for proper development of stress response and emotion-related behaviours. Epidemiological studies show that parental loss in childhood represents a major risk factor for the development of mental disorders throughout the ...
Natália Cristina Zanta +2 more
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Neighbourhood material deprivation and severe maternal morbidity: a population-based cohort study in Ontario, Canada [PDF]
BMJ Open, 2021 Objectives Rates of age-associated severe maternal morbidity (SMM) have increased in Canada, and an association with neighbourhood income is well established. Our aim was to examine SMM trends according to neighbourhood material deprivation quintile, and
Laura C Rosella +6 more
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Maternal Deprivation Increased Vulnerability to Depression in Adult Rats Through DRD2 Promoter Methylation in the Ventral Tegmental Area [PDF]
Frontiers in Psychiatry, 2022 ObjectiveEarly life adversity is a risk factor for depression in adulthood; however, the underlying mechanisms are not well understood. This study aims to investigate the effect of DNA methylation of DRD2 gene on early life stress–induced depression in ...
Zhenli Guo +8 more
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Maternal Deprivation in Rats Decreases the Expression of Interneuron Markers in the Neocortex and Hippocampus [PDF]
Frontiers in Neuroanatomy, 2021 Early life stress has profound effects on the development of the central nervous system. We exposed 9-day-old rat pups to a 24 h maternal deprivation (MD) and sacrificed them as young adults (60-day-old), with the aim to study the effects of early stress
Milan Aksic +10 more
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Spatial Learning Is Impaired in Male Pubertal Rats Following Neonatal Daily but Not Randomly Spaced Maternal Deprivation [PDF]
Frontiers in Cell and Developmental Biology, 2021 Severe early life stress has long been associated with neuropsychological disorders in adulthood, including depression, schizophrenia, post-traumatic stress disorder, and memory dysfunction.
Emily T. Stoneham +7 more
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The Relationship Between Parental Psychological Control and College Students’ Non-Suicidal Self-Injury: The Chain Mediation Roles of Relative Deprivation and Depression and the Moderating Role of Peer Relationships [PDF]
Behavioral SciencesPrevious research has demonstrated that parental psychological control increases the likelihood of non-suicidal self-injury (NSSI) among college students. However, the underlying mechanisms of this association remain unclear.
Sachula Cui, Qiang Bao
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Alterations of DNA Methylation at GDNF Gene Promoter in the Ventral Tegmental Area of Adult Depression-Like Rats Induced by Maternal Deprivation [PDF]
Frontiers in Psychiatry, 2019 Objective: To study the expression and DNA methylation of the Glial cell line-derived neurotrophic factor (GDNF) gene in the development of depression-like behaviors in rats experiencing maternal deprivation stress in early life.Methods: Newborn SD rats ...
Yi Zhang +6 more
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Long-Term Effects of Maternal Deprivation on the Volume of Dopaminergic Nuclei and Number of Dopaminergic Neurons in Substantia Nigra and Ventral Tegmental Area in Rats [PDF]
Frontiers in Neuroanatomy, 2020 Early life adversities leave long-lasting structural and functional consequences on the brain, which may persist later in life. Dopamine is a neurotransmitter that is extremely important in mood and motor control. The aim of this study was to investigate
Slobodan Kapor +9 more
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