The long-term effects of maternal deprivation on the number and size of inhibitory interneurons in the rat amygdala and nucleus accumbens [PDF]
Frontiers in Neuroscience, 2023 IntroductionThere is an increasing evidence supporting the hypothesis that traumatic experiences during early developmental periods might be associated with psychopathology later in life.
Dubravka Aleksic +9 more
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Neurobiological mechanisms involved in maternal deprivation-induced behaviours relevant to psychiatric disorders [PDF]
Frontiers in Molecular Neuroscience, 2023 Parental care is essential for proper development of stress response and emotion-related behaviours. Epidemiological studies show that parental loss in childhood represents a major risk factor for the development of mental disorders throughout the ...
Natália Cristina Zanta +2 more
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The impact of early life maternal deprivation on the perineuronal nets in the prefrontal cortex and hippocampus of young adult rats [PDF]
Frontiers in Cell and Developmental Biology, 2022 Early life stress negatively impacts brain development and affects structure and function of parvalbumin immunopositive (PV+) inhibitory neurons. Main regulators of PV+ interneurons activity and plasticity are perineuronal nets (PNNs), an extracellular ...
Ana Jakovljevic +8 more
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Maternal Deprivation in Rats Decreases the Expression of Interneuron Markers in the Neocortex and Hippocampus [PDF]
Frontiers in Neuroanatomy, 2021 Early life stress has profound effects on the development of the central nervous system. We exposed 9-day-old rat pups to a 24 h maternal deprivation (MD) and sacrificed them as young adults (60-day-old), with the aim to study the effects of early stress
Milan Aksic +10 more
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Maternal Deprivation Increased Vulnerability to Depression in Adult Rats Through DRD2 Promoter Methylation in the Ventral Tegmental Area [PDF]
Frontiers in Psychiatry, 2022 ObjectiveEarly life adversity is a risk factor for depression in adulthood; however, the underlying mechanisms are not well understood. This study aims to investigate the effect of DNA methylation of DRD2 gene on early life stress–induced depression in ...
Zhenli Guo +8 more
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Spatial Learning Is Impaired in Male Pubertal Rats Following Neonatal Daily but Not Randomly Spaced Maternal Deprivation [PDF]
Frontiers in Cell and Developmental Biology, 2021 Severe early life stress has long been associated with neuropsychological disorders in adulthood, including depression, schizophrenia, post-traumatic stress disorder, and memory dysfunction.
Emily T. Stoneham +7 more
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Long-Term Effects of Maternal Deprivation on the Volume of Dopaminergic Nuclei and Number of Dopaminergic Neurons in Substantia Nigra and Ventral Tegmental Area in Rats [PDF]
Frontiers in Neuroanatomy, 2020 Early life adversities leave long-lasting structural and functional consequences on the brain, which may persist later in life. Dopamine is a neurotransmitter that is extremely important in mood and motor control. The aim of this study was to investigate
Slobodan Kapor +9 more
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Effects of Maternal Deprivation and Complex Housing on Rat Social Behavior in Adolescence and Adulthood [PDF]
Frontiers in Behavioral Neuroscience, 2018 Early life context and stressful experiences are known to increase the risk of developing psychiatric disorders later in life, including disorders with deficits in the social domain.
Jiska Kentrop +9 more
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Alterations of DNA Methylation at GDNF Gene Promoter in the Ventral Tegmental Area of Adult Depression-Like Rats Induced by Maternal Deprivation [PDF]
Frontiers in Psychiatry, 2019 Objective: To study the expression and DNA methylation of the Glial cell line-derived neurotrophic factor (GDNF) gene in the development of depression-like behaviors in rats experiencing maternal deprivation stress in early life.Methods: Newborn SD rats ...
Yi Zhang +6 more
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Ketamine Reverses Lateral Habenula Neuronal Dysfunction and Behavioral Immobility in the Forced Swim Test Following Maternal Deprivation in Late Adolescent Rats [PDF]
Frontiers in Synaptic Neuroscience, 2018 Mounting evidence suggests that the long-term effects of adverse early life stressors on vulnerability to drug addiction and mood disorders are related to dysfunction of brain monoaminergic signaling in reward circuits. Recently, there has been a growing
Ryan D. Shepard +5 more
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