Results 241 to 250 of about 2,400,816 (305)

Pediatric Developmental Safety Assessment and New Approach Methodologies: US FDA/Triangle CERSI Workshop Report

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric developmental safety assessment presents distinct challenges in drug development. Children undergo dynamic changes in organ systems and drug disposition pathways during development, and drug‐related effects may be delayed or manifested differently than in adults.
Gilbert J. Burckart, Gelareh Abulwerdi, Christin L. Daniels, Calib Choi, Rebecca Racz, Jean‐Pierre Valentin, Kristin Ardlie, Nicholas Tatonetti, Susan Laffan, Marjory Moreau, Will Redfern, Lang Li, James J. Hickman, Rajanikanth Madabushi, Bhagwat Prasad, Lynne Yao, Paul B. Watkins   +16 more
wiley   +1 more source

Maternal Exposure to Ozone During Implantation Promotes a Feminized Transcriptomic Profile in the Male Adolescent Liver. [PDF]

Endocrinology
Dye JA, Stewart EJ, Schladweiler MC, Nguyen HH, Grindstaff RD, Padgett WT, Fisher AA, Miller CN.   +7 more
europepmc   +1 more source

Trust, but Verify: Translating Dosing Evidence to Understudied Populations in Low‐ and Middle‐Income Countries

Clinical Pharmacology &Therapeutics, EarlyView.
Drug dosing recommendations derived from healthy volunteers and selected preregistration populations may not translate reliably to physiologically distinct or understudied groups, particularly in low‐ and middle‐income countries. Using a metformin–dolutegravir drug interaction study and colistin pharmacokinetic study from South Africa, we illustrate ...
Roland van Rensburg, Veshni Pillay‐Fuentes Lorente, Eric Decloedt   +2 more
wiley   +1 more source

Racial disparities in maternal exposure to ambient air pollution during pregnancy and prevalence of congenital heart defects. [PDF]

Am J Epidemiol
Arogbokun Knutson OC, Luben TJ, Stingone JA, Engel LS, Martin CL, Olshan AF.   +5 more
europepmc   +1 more source

Advancing Pregnancy and Pediatric Science through the NIH Transporter Elucidation Network

Clinical Pharmacology &Therapeutics, EarlyView.
Human gestation is characterized by dynamic changes in maternal physiology and maturation of tissue functions before and after birth. The fetus and neonate are highly dependent upon transfer of maternal nutrients via the placenta and lactating mammary gland, which frequently involve selective membrane transporter proteins.
Joanne Wang, Jashvant D Unadkat, Samuel LM Arnold, John K Fallon, Pouria Fattahi, Dan Dongeun Huh, Nicholas Ieronimakis, Edward J Kelly, Svetlana Lutsenko, Robert M Stroud, Jacqueline B Tiley, Jia Yang, Xujia Zhou, Hao Zhu, Rajini Rao, Kathleen M Giacomini, Lauren M Aleksunes   +16 more
wiley   +1 more source

Maternal, fetal, and neonatal toxicity and potency estimates of perfluorohexane sulfonate (PFHxS) from oral maternal exposure in the Sprague-Dawley rat. [PDF]

Toxicology
Conley JM, Lambright CS, Evans N, Bangma J, Ford J, Hill D, Kakaley EM, Gray LE.   +7 more
europepmc   +1 more source

Medication Use During Breastfeeding—An Understudied Population: A Five‐Year Experience in the Pharmacovigilance Center of Lyon

Clinical Pharmacology &Therapeutics, EarlyView.
Medication use during breastfeeding is common, yet data on drug transfer into breast milk and infant exposure remain limited. This study describes real‐world requests concerning medication compatibility with breastfeeding managed by the Lyon pharmacovigilance center over five years.
Blandine Bertin, Aurore Gouraud, Anthony Facile, Fanny Ledys, Sabrina Pierre, Véronique Pizzoglio, Thierry Vial, Marine Auffret, Marina Atzenhoffer   +8 more
wiley   +1 more source

Association analysis of maternal exposure to air pollution during pregnancy and offspring asthma incidence. [PDF]

Reprod Health
Bao L, Liu Y, Zhang Y, Qian Q, Wang Y, Li W, Yu Y.   +6 more
europepmc   +1 more source

Does consumption of a high-fructose diet during pregnancy and lactation exacerbate the effects of maternal exposure to cadmium on development and metabolic function of mouse offspring? [PDF]

J Toxicol Environ Health A
Lau C, Das KP, Pancras JP, Strader LF, Narotsky MG, Dye JA, Moore ML, Kodavanti UP, Jackson TW, Wang X, Li JL, Bell DA, O'Neill J, Slotkin TA, Guyotte I, Carswell GK, Liu J, Corton JC, Chorley BN, Miller CN.   +19 more
europepmc   +1 more source

Maternal exposure to urban particulate matter induces cardiac developmental toxicity in zebrafish offspring by disrupting mitochondrial homeostasis. [PDF]

J Adv Res
Liu S, Ding R, Huang L, Lv J, Sun Z, Wang X, Duan J.   +6 more
europepmc   +1 more source