Atypical protein kinase C iota (PKCλ/ι) ensures mammalian development by establishing the maternal-fetal exchange interface. [PDF]
Proc Natl Acad Sci U S A, 2020 Abstract In utero mammalian development relies on the establishment of the maternal–fetal exchange interface, which ensures transportation of nutrients and gases between the mother and the fetus. This exchange interface is established via development of multinucleated syncytiotrophoblast cells (SynTs) during ...
Bhattacharya B +11 more
europepmc +4 more sources
Fetal–Fetal and Fetal–Maternal Microchimerism: Insights from Mammalian Placental Biology [PDF]
Journal of Developmental BiologyFeto-maternal microchimerism (Mc) refers to the exchange of cells between the fetus and mother, and fetal–fetal Mc to the exchange between fetuses during pregnancy. This phenomenon occurs across mammalian species, including humans, mice, and cattle.
Jorge A. De los Santos Funes
doaj +2 more sources
PLoS ONE, 2020 Human fetal thermoregulation, maternal-fetal heat exchange, and the role of the umbilical cord in these processes are not well understood. Ethical and technical limitations have restricted current knowledge to animal studies, that do not reflect human ...
Dorothea Kasiteropoulou +2 more
doaj +5 more sources
Placental Pathophysiology in Maternal Psychoactive Substance Use: Biological, Clinical, and Forensic Perspectives [PDF]
CellsMaternal psychoactive substance use during pregnancy represents a major threat to placental integrity and fetal development. As the central interface for maternal–fetal exchange, the placenta is highly susceptible to psychoactive substances, including ...
Oscar Fraile-Martinez +13 more
doaj +2 more sources
The GATA transcriptional program dictates cell fate equilibrium to establish the maternal-fetal exchange interface and fetal development. [PDF]
Proc Natl Acad Sci U S AThe placenta establishes a maternal–fetal exchange interface to transport nutrients and gases between the mother and the fetus. Establishment of this exchange interface relies on the development of multinucleated syncytiotrophoblasts (SynT) from trophoblast progenitors, and defect in SynT development often leads to pregnancy failure and impaired ...
Ghosh A +8 more
europepmc +3 more sources
Maternal obesity alters the placental transcriptome in a fetal sex-dependent manner
Frontiers in Cell and Developmental Biology, 2023 Infants born to obese mothers have an increased risk of developing obesity and metabolic diseases in childhood and adulthood. Although the molecular mechanisms linking maternal obesity during pregnancy to the development of metabolic diseases in ...
Amy Kelly +7 more
doaj +3 more sources
Uptake and release of amino acids in the fetal-placental unit in human pregnancies. [PDF]
PLoS ONE, 2017 OBJECTIVES:The current concepts of human fetal-placental amino acid exchange and metabolism are mainly based on animal-, in vitro- and ex vivo models.
Maia Blomhoff Holm +9 more
doaj +1 more source
Placental Development and Pregnancy-Associated Diseases
Maternal-Fetal Medicine, 2022 . Serving as the interface between the fetal and maternal environments during gestation, the placenta plays critical roles in the protection of the developing fetus and the maintenance of maternal health.
Xin Yu +6 more
doaj +1 more source
Maternal Oxygen Administration during Labor: A Controversial Practice
Children, 2023 Oxygen administration to the mother is commonly performed during labor, especially in the case of a non-reassuring fetal heart rate, aiming to increase oxygen diffusion through the placenta to fetal tissues.
Isabella Abati +5 more
doaj +1 more source
Omics Approaches to Study Formation and Function of Human Placental Syncytiotrophoblast
Frontiers in Cell and Developmental Biology, 2021 Proper development of the placenta is vital for pregnancy success. The placenta regulates exchange of nutrients and gases between maternal and fetal blood and produces hormones essential to maintain pregnancy.
Adam Jaremek +4 more
doaj +1 more source