Results 31 to 40 of about 638,233 (292)

Maternal tetanus toxoid vaccination and neonatal mortality in rural North India [PDF]

, 2015
Objectives: Preventable neonatal mortality due to tetanus infection remains common. We aimed to examine antenatal vaccination impact in a context of continuing high neonatal mortality in rural northern India.
Singh, Abhishek, William Stones, Ogollah, Reuben, Stones, William, Reuben Ogollah, Pallikadavath, Saseendran, Saseendran Pallikadavath, Abhishek Singh   +7 more
core   +1 more source

Shifting Child Protection Assessments From a Deficit Focus to Assessments Informed by Strengths and Protective Factors: Translating Research Knowledge to Practice

Australian Journal of Social Issues, EarlyView.
ABSTRACT Child protection systems play a critical role in preventing and responding to child maltreatment, yet practices are often predominantly deficit focused. This paper presents a rapid literature review on the strengths, protective factors, and cultural considerations to inform child protection assessment.
Gabrielle R. Hunt, Carmela Bastian, Luke Cantley, Ulrike Marwitz, Daryl J. Higgins   +4 more
wiley   +1 more source

The Role of IgM Anti‐acetylated Protein Antibodies and B Cells in the Origin of Antimodified Protein Autoimmunity in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis (RA) is characterized by anti‐modified protein antibodies (AMPAs), including anti‐citrullinated protein antibodies (ACPA), anti‐carbamylated protein antibodies (anti‐CarP), and anti‐acetylated protein antibodies (AAPA). In contrast to other AMPAs, AAPA IgM is found in healthy individuals, raising questions about its role ...
Aegli Athanasiadou, Sanne Kroos, Renee van de Wetering, Rian Schopmeijer, Carin van der Keur, Michael Eikmans, Caroline Meijer, Solbritt Rantapää‐Dahlqvist, René E. M. Toes, Linda M. Slot, Diane van der Woude   +10 more
wiley   +1 more source

Factors Affecting Maternal Behavior in Achieving Complete Basic Immunization for Toddlers Aged 12–23 in Banggai Laut Regency, Indonesia

National Journal of Community Medicine
Background: Complete Basic Immunization (CBI) is essential to prevent vaccine-preventable diseases (VPDs). However, the coverage of complete basic immunization in Banggai Laut Regency remains low at 67.9%, compared to the national target of 90%. Several
Amrin Madolan, Ridwan M Thaha, Muhammad Syafar, Sudirman Nasir, Nurhaedar Jafar, A Arsunan Arsin   +5 more
doaj   +3 more sources

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

Maternal characteristics as predictors of immunization status of under-five in Ebonyi State of Nigeria. A community based cross-sectional study

, 2022
Background: : Childhood immunization with the interacting factors has been a significant public health challenge especially in the sub-Saharan Africa. Nigeria has been presented as one the countries with the worst under-five mortality rates, and factors ...
Sylvester, Edu Theresa, Omaka-Amari, Lois N., Afoke, Eunice N., Nwafor, Jude N., Okereke, Michael O., Ikechukwu, Ilo Cajetan, Ochiaka, Raphael E., Aleke, Christian O., Edet, Bassey Rita   +8 more
core  

Phase I Evaluation of Siltartoxatug, a First‐in‐Class Anti‐Tetanus Monoclonal Antibody: Safety, Pharmacokinetics and Pharmacodynamics in Healthy Australian and Chinese Populations

Clinical Pharmacology &Therapeutics, EarlyView.
Siltartoxatug, a first‐in‐class monoclonal antibody targeting tetanus toxin for post‐exposure prophylaxis, was evaluated in two phase I trials in Australian and Chinese healthy adults. In these randomized, double‐blind, placebo‐controlled, dose‐escalation studies, participants received a single intramuscular injection of siltartoxatug (10–250 μg/kg) or
Xinyu Liu, Zhigang Liu, Xiaohu Kuang, Yueming Wang, Xiaoyi Liu, Jiyuan Ding, Xia Zhou, Xin Zhou, Qianyu Liang, Meizhuo Zhang, Hao Zhao, Qingqing Tan, Weihong Zheng, Huaxin Liao, Charlotte Lemech, Wanmei Wang   +15 more
wiley   +1 more source

Current Challenges and Achievements in Maternal Immunization Research

Frontiers in Immunology, 2018
Maternal immunization has the potential to significantly improve maternal and child health worldwide by reducing maternal and infant morbidity and mortality associated with disease caused by pathogens that are particularly relevant in the perinatal ...
Flor M. Munoz, Flor M. Munoz
doaj   +1 more source

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley   +1 more source

Maternal DTaP immunization and transplacental transfer of pertussis antibodies in Japan

International Journal of Infectious Diseases
Background: Maternal pertussis immunization prevents severe infection in early infancy. In Japan, the diphtheria–tetanus–acellular pertussis (DTaP) vaccine is available during pregnancy, whereas the tetanus–diphtheria–acellular pertussis (Tdap) vaccine ...
Kazuya Hiiragi, Ryosuke Shindo, Tomoyuki Kojima, Sayuri Nakanishi, Soichiro Obata, Etsuko Miyagi, Shigeru Aoki   +6 more
doaj   +1 more source