Results 51 to 60 of about 3,183,824 (240)

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Age-Dependent Dynamics of Maternally Derived Antibodies (MDAs) and Understanding MDA-Mediated Immune Tolerance in Foot-and-Mouth Disease-Vaccinated Pigs

Vaccines, 2022
Vaccine-induced active immunity in young animals may be compromised via interference caused by maternally derived antibodies (MDAs). Since the level, titer, and half-life of MDAs vary per individual, it is difficult to determine the appropriate timing of
Sehee Shin, So Hui Park, Jong-Hyeon Park, Su-Mi Kim, Min Ja Lee   +4 more
doaj   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

A prospective nested case-control study of Dengue in infants: rethinking and refining the antibody-dependent enhancement dengue hemorrhagic fever model. [PDF]

PLoS Medicine, 2009
Dengue hemorrhagic fever (DHF) is the severe and life-threatening syndrome that can develop after infection with any one of the four dengue virus (DENV) serotypes.
Daniel H Libraty, Luz P Acosta, Veronica Tallo, Edelwisa Segubre-Mercado, Analisa Bautista, James A Potts, Richard G Jarman, In-Kyu Yoon, Robert V Gibbons, Job D Brion, Rosario Z Capeding   +10 more
doaj   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

DECLINE OF MATERNAL ANTIBODIES AGAINST SWINE INFLUENZA A AND PRRS IN PIGLETS FROM DIFFERENT SOW VACCINATION PROGRAMS

Archives of Veterinary Medicine
The primary objective of this study was to evaluate the effect of sow influenza vaccination timing on the persistence and decay of maternally derived antibodies (MDAs) against swine influenza A virus (IAV-S) in piglets.
Vesna Milićević, Slaviša Stojković, Sofija Šolaja, Dimitrije Glišić, Snežana Ristevski, Dragan Ristevski, Gordana Ristić, Vladan Miljković   +7 more
doaj   +1 more source

Paternal Sperm Gnas‐ICR Epigenetic Programming Contributes to PPP‐Like Phenotypes in Female Offspring

Advanced Science, EarlyView.
A paternal glucocorticoid–sperm Gnas‐ICR axis is linked to ovarian endocrine programming in female offspring. Paternal preconception caffeine exposure elevates corticosterone, promotes sperm Gnas‐ICR hypermethylation, and is associated with ovarian Gnas upregulation, cAMP/PKA/CREB–StAR activation, enhanced estradiol synthesis, and PPP‐like phenotypes ...
Jing Huang, Lu Chen, Tiancheng Wu, Yating Li, Hui Wang   +4 more
wiley   +1 more source

A randomized controlled study on the efficacy of a novel combination vaccine against enzootic pneumonia (Mycoplasma hyopneumoniae) and porcine Circovirus type 2 (PCV2) in the presence of strong maternally derived PCV2 immunity in pigs

BMC Veterinary Research, 2017
Background Mycoplasma hyopneumoniae (M. hyo) and Porcine Circovirus Type 2 (PCV2) are major pathogens that cause significant health problems in swine worldwide.
Panagiotis D. Tassis, Ioannis Tsakmakidis, Vassileios G. Papatsiros, Dimitrios Koulialis, Tom Nell, Georgia Brellou, Eleni D. Tzika   +6 more
doaj   +1 more source

Maternal Immunization: Nature Meets Nurture

Frontiers in Microbiology, 2020
Vaccinating women in pregnancy (i.e., maternal immunization) has emerged as a promising tool to tackle infant morbidity and mortality worldwide.
Anja Saso, Anja Saso, Beate Kampmann, Beate Kampmann   +3 more
doaj   +1 more source

THE EFFECT OF MATERNALLY DERIVED ANTIBODIES ON THE RESPONSE OF CALVES TO VACCINATION AGAINST KABETE O RINDERPEST VACCINE [PDF]

Veterinary Medical Journal - Giza, 2005
A study was undertaken to find out the age at which calves borne to repeatedly vaccinated dame could be vaccinated against rinderpest (RP). Eight vaccination regimes on eight groups of colostrum-fed calves were implemented using a local live attenuated ...
A Al-sukyran, A Banna, S Hafez, M Farag
doaj   +1 more source