Results 41 to 50 of about 504,188 (310)
A comparison of embedding aggregation strategies in drug–target interaction prediction
BMC BioinformaticsThe prediction of interactions between novel drugs and biological targets is a vital step in the early stage of the drug discovery pipeline. Many deep learning approaches have been proposed over the last decade, with a substantial fraction of them ...
Dimitrios Iliadis +3 more
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Weyl metrics and Wiener-Hopf factorization
Journal of High Energy Physics, 2020 We consider the Riemann-Hilbert factorization approach to the construction of Weyl metrics in four space-time dimensions. We present, for the first time, a rigorous proof of the remarkable fact that the canonical Wiener-Hopf factorization of a matrix ...
P. Aniceto +3 more
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CoRR, 2016 Musical chords, harmonies or melodies in Just Intonation have note frequencies which are described by a base frequency multiplied by rational numbers. For any local section, these notes can be converted to some base frequency multiplied by whole positive numbers.
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FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Improving mathematics diagnostic tests using item analysis [PDF]
, 2023 Meike Akveld, George Kinnear
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The Critical Strips of the Sums 1+2𝑧+⋯+𝑛𝑧
Abstract and Applied Analysis, 2011 We give a partition of the critical strip, associated with each partial sum 1+2𝑧+⋯+𝑛𝑧 of the Riemann zeta function for Re ...
G. Mora, J. M. Sepulcre
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Mathematical analysis of Cuboctahedron
, 2014 A cuboctahedron is a solid that has 8 congruent equilateral triangular & 6 congruent square faces, each having equal edge length. It is made/generated either by cutting off all the vertices (corners) of a cube (having 8 vertices & 6 congruent square faces) or by cutting off all the vertices (corners) of a regular octahedron (having 6 vertices & 8 ...
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