Results 21 to 30 of about 1,943,789 (312)

Mathematics at the eve of a historic transition in biology

open access: yes, 2017
A century ago physicists and mathematicians worked in tandem and established quantum mechanism. Indeed, algebras, partial differential equations, group theory, and functional analysis underpin the foundation of quantum mechanism.
Wei, Guo-Wei
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Peak reduction technique in commutative algebra

open access: yes, 1999
The "peak reduction" method is a powerful combinatorial technique with applications in many different areas of mathematics as well as theoretical computer science.
D Wright   +11 more
core   +2 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Homotopy moment maps

open access: yes, 2016
Associated to any manifold equipped with a closed form of degree >1 is an `L-infinity algebra of observables' which acts as a higher/homotopy analog of the Poisson algebra of functions on a symplectic manifold.
Callies, Martin   +3 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Applying Graph Theory to Examine the Dynamics of Student Discussions in Small-Group Learning. [PDF]

open access: yes, 2019
Group work in science, technology, engineering, and mathematics courses is an effective means of improving student outcomes, and many different factors can influence the dynamics of student discussions and, ultimately, the success of collaboration.
Chai, Albert   +3 more
core   +1 more source

Anomaly constraints and string/F-theory geometry in 6D quantum gravity

open access: yes, 2010
Quantum anomalies, determined by the Atiyah-Singer index theorem, place strong constraints on the space of quantum gravity theories in six dimensions with minimal supersymmetry.
Taylor, Washington
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

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