Results 21 to 30 of about 14,536,524 (252)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
A geometric characterization of the upper bound for the span of the jones polynomial [PDF]
, 2011 Let D be a link diagram with n crossings, sA and sB be its extreme states and |sAD| (respectively, |sBD|) be the number of simple closed curves that appear when smoothing D according to sA (respectively, sB). We give a general formula for the sum |sAD| +
PEDRO M. G. MANCHÓN +4 more
core +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Digital technology in mathematics education: Why it works (or doesn't) [PDF]
, 2012 The integration of digital technology confronts teachers, educators and researchers with many questions. What is the potential of ICT for learning and teaching, and which factors are decisive in making it work in the mathematics classroom? To investigate
Drijvers, Paul +3 more
core +2 more sources
Troubling "understanding mathematics-in-depth": Its role in the identity work of student-teachers in England [PDF]
, 2013 Copyright @ The Author(s) 2013. This article is published with open access at Springerlink.comThis article has been made available through the Brunel Open Access Publishing Fund.In this paper, we focus on an initiative in England devised to prepare non ...
Adler, Jill +8 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Making mathematics meaningful: Using student-initiated problems to situate mathematics [PDF]
, 2014 Mathematics is everywhere-from the minute we open our eyes to check the alarm clock and calculate how many minutes extra we can afford to lie in bed, to measuring out our cereal for breakfast and estimating if we have enough petrol to make the 18 ...
Brough, Chris Jane, Calder, Nigel Stuart
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Students' perspectives on the nature of mathematics [PDF]
, 2006 This paper reports on one small component of a much larger study that explored the perspectives of students towards mathematics learning. Students were asked “What do you think maths is all about?” Some students responded in terms of mathematical content.
Taylor, Merilyn +3 more
core +1 more source
Experimental mathematics and its use in number theory
Vestnik Tomskogo gosudarstvennogo universiteta. Matematika i mekhanika, 2022 The purpose of the work is to show the usefulness and features of experimental mathematics. Two number theory problems are solved using Wolfram Mathematica. The solution to the first problem has already been published. Congruencies of the form F(A(p)) ≡ εF(S) (mod p) by prime modulo p are proved, whenever A(p) is a polynomial respect p with integer ...
openaire +1 more source