Results 21 to 30 of about 56,762 (219)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Heterogeneous mathematical models in numerical analysis of structures
Computers & Mathematics with Applications, 2001 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Savula, Y.H., Dyyak, I.I., Krevs, V.V.
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From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Frontiers in mathematical analysis and numerical methods [PDF]
, 2004 This invaluable volume is a collection of articles in memory of Jacques-Louis Lions, a leading mathematician and the founder of the contemporary French Applied Mathematics School. The contributions have been written by his friends, colleagues and students, including C Bardos, A Bensoussan, S S Chern, P G Ciarlet, R Glowinski, Gu Chaohao, B Malgrange, G
Bardos, Claude, Guo, Y., Strauss, W.
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Mathematical analysis and numerical simulation of a model of morphogenesis
Mathematical Biosciences and Engineering, 2011 We consider a simple mathematical model of distribution of morphogens (signaling molecules responsible for the differentiation of cells and the creation of tissue patterns). The mathematical model is a particular case of the model proposed by Lander, Nie and Wan in 2006 and similar to the model presented in Lander, Nie, Vargas and Wan 2005.
Ana I. Muñoz, José Ignacio Tello
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Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Modeling, Mathematical and Numerical Analysis of Electrorheological Fluids [PDF]
Applications of Mathematics, 2004 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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