Results 41 to 50 of about 24,354,110 (247)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Analytical and numerical investigation of mixed-type functional differential equations [PDF]
, 2009 NOTICE: this is the author’s version of a work that was accepted for publication in Journal of computational and applied mathematics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and ...
Ford, Neville J. +3 more
core +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Heterogeneous mathematical models in numerical analysis of structures
Computers & Mathematics with Applications, 2001 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Savula, Y.H., Dyyak, I.I., Krevs, V.V.
openaire +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Frontiers in mathematical analysis and numerical methods [PDF]
, 2004 This invaluable volume is a collection of articles in memory of Jacques-Louis Lions, a leading mathematician and the founder of the contemporary French Applied Mathematics School. The contributions have been written by his friends, colleagues and students, including C Bardos, A Bensoussan, S S Chern, P G Ciarlet, R Glowinski, Gu Chaohao, B Malgrange, G
Bardos, Claude, Guo, Y., Strauss, W.
openaire +3 more sources
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Modeling, Mathematical and Numerical Analysis of Electrorheological Fluids [PDF]
Applications of Mathematics, 2004 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +3 more sources
Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova +9 more
wiley +1 more source