Results 41 to 50 of about 1,907,959 (313)
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Robust Iterative Solution of a Class of Time-Dependent Optimal Control Problems [PDF]
, 2012 The fast iterative solution of optimal control problems, and in particular PDE-constrained optimization problems, has become an active area of research in applied mathematics and numerical analysis.
Pearson, John W. +2 more
core +1 more source
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
Journal of Applied Mathematics, 2011 The interaction between fluid and structure occurs in a wide range of engineering problems. The solution for such problems is based on the relations of continuum mechanics and is mostly solved with numerical methods.
F. Benra +4 more
semanticscholar +1 more source
‘Balancing’ the ‘live’ use of resources towards the introduction of the iterative numerical method [PDF]
, 2019 This paper draws on the Knowledge Quartet (Rowland, Huckstep, & Thwaites, 2005) to analyse an introductory to the Iterative Numerical Method Year 13 lesson of a secondary mathematics teacher who uses a range of paper based and electronic resources ...
Biza, Irene, Kayali, Lina
core +1 more source
Optimization of Dengue Epidemics: a test case with different discretization schemes [PDF]
, 2009 The incidence of Dengue epidemiologic disease has grown in recent decades. In this paper an application of optimal control in Dengue epidemics is presented.
Ch. Tsitouras +5 more
core +2 more sources
Molecular Oncology, EarlyView.We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin +10 more
wiley +1 more source
The history of the concept of function and some educational implications [PDF]
, 1992 Several fields of mathematics deal directly or indirectly with functions: mathematical analysis considers functions of one, two, or n variables, studying their properties as well as those of their derivatives; the theories of differential and integral ...
Ponte, João Pedro da
core
Molecular Oncology, EarlyView.Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf +10 more
wiley +1 more source
Detailed mathematical and numerical analysis of a dynamo model [PDF]
Astronomy & Astrophysics, 2014 We investigate the role of nonlinear feedback by α-quenching, flux losses, and feedback by differential rotations in dynamo. Specifically, by studying the nonlinear dynamo model analytically and numerically, we unfold how frequency p of magnetic field, magnetic field strength |B|, and phase φ are influenced by different types of nonlinear feedback in ...
Eun Jin Kim, Aditi Sood
openaire +2 more sources