Results 121 to 130 of about 2,604,528 (199)

Circumventing glioblastoma resistance to temozolomide through optimal drug combinations designed by systems pharmacology and machine learning

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Glioblastoma (GBM), the most frequent and aggressive brain tumour in adults, is associated with a dismal prognostic despite intensive treatment involving surgery, radiotherapy and temozolomide (TMZ)‐based chemotherapy. The initial or acquired resistance of GBM to TMZ appeals for precision medicine approaches to the design of ...
Sergio Corridore   +6 more
wiley   +1 more source

Multi‐response phylogenetic mixed models: concepts and application

open access: yesBiological Reviews, EarlyView.
ABSTRACT The scale and resolution of trait databases and molecular phylogenies is increasing rapidly. These resources permit many open questions in comparative biology to be addressed with the right statistical tools. Multi‐response (MR) phylogenetic mixed models (PMMs) offer great potential for multivariate analyses of trait evolution.
Ben Halliwell   +2 more
wiley   +1 more source

Revisiting concepts of thermal physiology: understanding negative feedback and set‐point in mammals, birds, and lizards

open access: yesBiological Reviews, EarlyView.
Abstract The thermoregulatory system of homeothermic endotherms operates to attain thermal equilibrium, that is no net loss or gain of heat, where possible, under a thermal challenge, and not to attain a set‐point or any other target body temperature.
Duncan Mitchell   +5 more
wiley   +1 more source

Higher Structure of Chiral Symmetry. [PDF]

open access: yesCommun Math Phys
Copetti C   +3 more
europepmc   +1 more source

Richard V. Kadison (1925-2018). [PDF]

open access: yesProc Natl Acad Sci U S A, 2019
Rieffel MA.
europepmc   +1 more source

VortexTransformer: End‐to‐End Objective Vortex Detection in 2D Unsteady Flow Using Transformers

open access: yesComputer Graphics Forum, EarlyView.
Abstract Vortex structures play a pivotal role in understanding complex fluid dynamics, yet defining them rigorously remains challenging. One hard criterion is that a vortex detector must be objective, i.e., it needs to be indifferent to reference frame transformations.
X. Zhang, P. Rautek, M. Hadwiger
wiley   +1 more source

Categorial modal realism. [PDF]

open access: yesSynthese, 2023
Brunet TDP.
europepmc   +1 more source

Inverse Simulation of Radiative Thermal Transport

open access: yesComputer Graphics Forum, EarlyView.
Abstract The early phase of urban planning and architectural design has a great impact on the thermal loads and characteristics of constructed buildings. It is, therefore, important to efficiently simulate thermal effects early on and rectify possible problems.
C. Freude   +5 more
wiley   +1 more source

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