Results 111 to 120 of about 394,950 (308)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The somatic cost of reproduction: what determines reproductive effort in prime-aged fallow bucks? [PDF]

, 2003
The somatic costs of reproduction are important for understanding the relationship between sexual selection and life-history evolution, and there are two main hypotheses used to explain the pattern of reproductive effort in ungulates.
Hayden, T J, Hayden, TJ, Naulty, F, McElligott, AG, Clarke, WV, McElligott, A G, Clarke, W V   +6 more
core   +1 more source

Transferencia de espermatóforos en el camarón de roca Rhynchocinetes typus (Caridea: Rhynchocinetidae) Spermatophores transference in the rock shrimp Rhynchocinetes typus (Caridea: Rhynchocinetidae)

Latin American Journal of Aquatic Research, 2010
Se estableció la forma en que los machos del camarón Rhynchocinetes typus transfieren los espermatoforos durante la cópula. La fecundación es externa y durante el apareamiento, el primer y segundo par de pleopodos masculinos tienen una activa ...
Rubí Martínez, Enrique Dupré
doaj  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Impact of diverse musical genres on blood-feeding and mating behavior in Aedes aegypti mosquitoes

Journal of Vector Borne Diseases
Background & objectives: Sound plays an important role in mosquito foraging and sexual interactions. Mosquitoes utilize acoustic signals for host location, sexual recognition, and mating, which is achieved through the rhythmic beating of their wings to ...
Chew Yan Ni, Nur Faeza Abu Kassim, Noor Moukhni Ayub, Sara Abdelrahman Abuelmaali, Abadi M. Mashlawi, Hamady Dieng   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Juvenile hormone regulates the maturation of sexually dimorphic naive ethanol olfactory preference in Drosophila melanogaster

Royal Society Open Science
The molecular mechanisms underlying the maturation of innate reward behaviours remain poorly understood. We have identified a sexually dimorphic innate reward behaviour in Drosophila melanogaster that varies depending on the age, sex and mating status in
Antonio Marini-Davis, Ryan Oliver, Bailey Godwin, Sera Chase, Ziam Khan, Fernando J. Vonhoff   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Uncertain Paternity, Mating Market Failure, and the Institution of Marriage [PDF]

This paper provides a first microeconomic foundation for the institution of marriage. Based on a model of reproduction, mating, and parental investment in children, we argue that marriage serves the purpose of attenuating the risk of mating market ...
Michael Kvasnicka, Dirk Bethmann
core  

Drosophila Males Differentially Express Small Proteins Regulating Stem Cell Division Frequency in Response to Mating

Journal of Developmental Biology
The germline stem cells (GSCs) in the male gonad of Drosophila can increase their division frequency in response to a demand for more sperm caused by repeated mating.
Manashree S. Malpe, Leon F. McSwain, Heath M. Aston, Karl A. Kudyba, Chun Ng, Megan P. Wright, Cordula Schulz   +6 more
doaj   +1 more source