Results 121 to 130 of about 394,950 (308)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Young adults' sexual strategies and mating displays in the virtual world: an evolutionary perspective [PDF]
, 2013 Includes bibliographical references.Life History Theory (LHT) predicts that natural selection favours a degree of developmental plasticity when it comes to sexual strategies and mating displays.
Swanepoel, Tarah
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Deep learning reveals endogenous sterols as allosteric modulators of the GPCR–Gα interface
eLifeEndogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for unbiased cavity identification, cavity-specific ligand
Sanjay Kumar Mohanty +17 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Frontiers in PsychologyIntroductionGrounded in belongingness theory, the goal of this study is to understand the consequences of ghosting (an approach to ending relationships that involves ending all forms of communication with someone without explanation) on objective and ...
Michael R. Langlais +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Mating-type switching in S. pombe.
, 2018 (A) The mat1 locus is expressed and confers cell type. The silent loci mat2-P and mat3-M serve as donors of genetic information to interconvert the mat1-P and mat1-M alleles.
Geneviève Thon (13482) +4 more
core +1 more source
InsectsBumblebees are key pollinators in agricultural and natural ecosystems; however, climate change is driving shifts in population size, body size, and diversity.
Min Su Park +7 more
doaj +1 more source