Results 121 to 130 of about 1,047,812 (348)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Juvenile hormone regulates the maturation of sexually dimorphic naive ethanol olfactory preference in Drosophila melanogaster

Royal Society Open Science
The molecular mechanisms underlying the maturation of innate reward behaviours remain poorly understood. We have identified a sexually dimorphic innate reward behaviour in Drosophila melanogaster that varies depending on the age, sex and mating status in
Antonio Marini-Davis, Ryan Oliver, Bailey Godwin, Sera Chase, Ziam Khan, Fernando J. Vonhoff   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Drosophila Males Differentially Express Small Proteins Regulating Stem Cell Division Frequency in Response to Mating

Journal of Developmental Biology
The germline stem cells (GSCs) in the male gonad of Drosophila can increase their division frequency in response to a demand for more sperm caused by repeated mating.
Manashree S. Malpe, Leon F. McSwain, Heath M. Aston, Karl A. Kudyba, Chun Ng, Megan P. Wright, Cordula Schulz   +6 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Deep learning reveals endogenous sterols as allosteric modulators of the GPCR–Gα interface

eLife
Endogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for unbiased cavity identification, cavity-specific ligand
Sanjay Kumar Mohanty, Aayushi Mittal, Namra Farooqi, Aakash Gaur, Subhadeep Duari, Saveena Solanki, Anmol Kumar Sharma, Sakshi Arora, Suvendu Kumar, Vishakha Gautam, Nilesh Kumar Dixit, Karthika Subramanian, Tarini Shankar Ghosh, Debarka Sengupta, Shashi Kumar Gupta, Arul Natarajan Murugan, Deepak Sharma, Gaurav Ahuja   +17 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Resilience to ghosting? A randomized controlled trial examining the consequences of ghosting on sleep quality in potential romantic relationships

Frontiers in Psychology
IntroductionGrounded in belongingness theory, the goal of this study is to understand the consequences of ghosting (an approach to ending relationships that involves ending all forms of communication with someone without explanation) on objective and ...
Michael R. Langlais, Anabelen Pons, Olivia Dechert, Anna M. Murvich, Jeremy A. Bigalke   +4 more
doaj   +1 more source

Daze fasteners [PDF]

, 1985
A daze fastener system for connecting two or more structural elements wherein the structural elements and fastener parts have substantially different coefficient of thermal expansion physical property characteristics is employed in this invention.
Davis, R. C., Jackson, L. R., Taylor, A. H.   +2 more
core   +1 more source