Results 171 to 180 of about 17,602,067 (294)

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Mating system of free-ranging domestic dogs and its consequences for dog evolution. [PDF]

Proc Natl Acad Sci U S A
Car C, Adavoudi R, Berghänel A, Vanderheyden M, Moura AE, Range F, Cimarelli G, Lazzaroni M, Dale R, El Berbri I, Spatola GJ, Mousseau TA, Marshall-Pescini S, Pilot M.   +13 more
europepmc   +1 more source

Genetic analysis and physiological relationships of drought response in fennel: Interaction with mating system. [PDF]

PLoS One, 2022
Hosseini E, Majidi MM, Saeidnia F, Ehtemam MH.   +3 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Investigating the consequences of the mating system for drug resistance evolution in <i>Caenorhabditis elegans</i>. [PDF]

Proc Biol Sci
Trubenová B, Hellinga J, Krücken J, von Samson-Himmelstjerna G, Schulenburg H, Regoes RR.   +5 more
europepmc   +1 more source

The selfing syndrome and beyond: diverse evolutionary consequences of mating system transitions in plants. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2022
Tsuchimatsu T, Fujii S.
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Exogenous hormones regulate the sequentially reproductive output in Pseudostellaria heterophylla with a chasmogamous-cleistogamous mixed mating system. [PDF]

Sci Rep
Sun Q, Wu L, Zhao JM, Zhang YW.
europepmc   +1 more source

Competitive ability depends on mating system and ploidy level across Capsella species. [PDF]

Ann Bot, 2022
Orsucci M, Yang X, Vanikiotis T, Guerrina M, Duan T, Lascoux M, Glémin S.   +6 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source