Results 21 to 30 of about 4,889 (164)
Oculocutaneous albinism type 4: Novel compound heterozygous mutations in the SLC45A2 gene in a Chinese case. [PDF]
Mol Genet Genomic MedIn this study, we present a case with less pigmented hair and fairer than normal skin. Strabismus, hyperopia, astigmatism and the absence of iris pigment were found in his both eyes. Whole exome sequencing was performed in all samples, and Sanger sequencing was then used to verify the mutations. Compound heterozygous variants, c.1304C>A (p.S435Y) and c.
He D +6 more
europepmc +2 more sources
Mapping Topoisomerase IV Binding and Activity Sites on the E. coli Genome. [PDF]
PLoS Genetics, 2016 Catenation links between sister chromatids are formed progressively during DNA replication and are involved in the establishment of sister chromatid cohesion.
Hafez El Sayyed +7 more
doaj +1 more source
mBio, 2019 Division ring formation at midcell is controlled by various mechanisms in Escherichia coli, one of them being the linkage between the chromosomal Ter macrodomain and the Z-ring mediated by MatP, a DNA binding protein that organizes this macrodomain and ...
Begoña Monterroso +9 more
doaj +1 more source
Long-range chromosome organization in E. coli: a site-specific system isolates the Ter macrodomain. [PDF]
PLoS Genetics, 2012 The organization of the Escherichia coli chromosome into a ring composed of four macrodomains and two less-structured regions influences the segregation of sister chromatids and the mobility of chromosomal DNA. The structuring of the terminus region (Ter)
Axel Thiel +4 more
doaj +1 more source
Biology, 2023 The MATP/tau protein is hyperphosphorylated in Alzheimer’s patients. Therefore, research into the regulation of tau protein phosphorylation is important for understanding Alzheimer’s disease.
Hiromitsu Tanaka +4 more
doaj +1 more source
Immunological Reviews, Volume 318, Issue 1, Page 37-50, September 2023., 2023 Summary Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy. However, their use is frequently associated with immune‐related adverse events (irAEs) potentially affecting any organ. The mechanisms mediating such irAEs remain poorly understood and biomarkers to predict the development of irAEs are lacking.
Fiamma Berner, Lukas Flatz
wiley +1 more source
Evidence for divisome localization mechanisms independent of the Min system and SlmA in Escherichia coli. [PDF]
PLoS Genetics, 2014 Cell division in Escherichia coli starts with assembly of FtsZ protofilaments into a ring-like structure, the Z-ring. Positioning of the Z-ring at midcell is thought to be coordinated by two regulatory systems, nucleoid occlusion and the Min system. In E.
Matthew W Bailey +4 more
doaj +1 more source
Alkaline pH-Driven Metabolic Plasticity of Lactococcus lactis FM03. [PDF]
Environ MicrobiolAlkaline pH induces a metabolic shift in Lactococcus lactis FM03 from mixed‐acid to homolactic fermentation, driven by proteome‐level constraints in the mixed‐acid branch. This shift reduces biomass yield despite unchanged bioenergetics. Moreover, alkaline pH changes cell morphology and prevents elongation at higher growth rates.
Bendig TAL +4 more
europepmc +2 more sources
A MatP–divisome interaction coordinates chromosome segregation with cell division in E. coli [PDF]
The EMBO Journal, 2012 Initiation of chromosome segregation in bacteria is achieved by proteins acting near the origin of replication. Here, we report that the precise choreography of the terminus region of the Escherichia coli chromosome is also tightly controlled. The segregation of the terminus (Ter) macrodomain (MD) involves the structuring factor MatP.
Olivier, Espéli +6 more
openaire +2 more sources
Linearised Higher Variational Equations [PDF]
, 2014 This work explores the tensor and combinatorial constructs underlying the linearised higher-order variational equations of a generic autonomous system along a particular solution.
Simon, Sergi
core +3 more sources