Competitive binding of MatP and topoisomerase IV to the MukB dimerization hinge [PDF]
, 2021 ABSTRACTSMC complexes have ubiquitous roles in chromosome organisation. InEscherichia coli,the interplay between the SMC complex, MukBEF, and matS-bound MatP in the replication termination region, ter, results in depletion of MukBEF from ter, thus promoting chromosome individualisation by directing replichores to separate cell halves.
Gemma L. M. Fisher +10 more
openaire +1 more source
Differential management of the replication terminus regions of the two Vibrio cholerae chromosomes during cell division. [PDF]
PLoS Genetics, 2014 The replication terminus region (Ter) of the unique chromosome of most bacteria locates at mid-cell at the time of cell division. In several species, this localization participates in the necessary coordination between chromosome segregation and cell ...
Gaëlle Demarre +6 more
doaj +1 more source
Mapping Topoisomerase IV Binding and Activity Sites on the E. coli Genome. [PDF]
PLoS Genetics, 2016 Catenation links between sister chromatids are formed progressively during DNA replication and are involved in the establishment of sister chromatid cohesion.
Hafez El Sayyed +7 more
doaj +1 more source
Biology, 2023 The MATP/tau protein is hyperphosphorylated in Alzheimer’s patients. Therefore, research into the regulation of tau protein phosphorylation is important for understanding Alzheimer’s disease.
Hiromitsu Tanaka +4 more
doaj +1 more source
Long-range chromosome organization in E. coli: a site-specific system isolates the Ter macrodomain. [PDF]
PLoS Genetics, 2012 The organization of the Escherichia coli chromosome into a ring composed of four macrodomains and two less-structured regions influences the segregation of sister chromatids and the mobility of chromosomal DNA. The structuring of the terminus region (Ter)
Axel Thiel +4 more
doaj +1 more source
Immunological Reviews, Volume 318, Issue 1, Page 37-50, September 2023., 2023 Summary Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy. However, their use is frequently associated with immune‐related adverse events (irAEs) potentially affecting any organ. The mechanisms mediating such irAEs remain poorly understood and biomarkers to predict the development of irAEs are lacking.
Fiamma Berner, Lukas Flatz
wiley +1 more source
Evidence for divisome localization mechanisms independent of the Min system and SlmA in Escherichia coli. [PDF]
PLoS Genetics, 2014 Cell division in Escherichia coli starts with assembly of FtsZ protofilaments into a ring-like structure, the Z-ring. Positioning of the Z-ring at midcell is thought to be coordinated by two regulatory systems, nucleoid occlusion and the Min system. In E.
Matthew W Bailey +4 more
doaj +1 more source
Transcription start site scanning and the requirement for ATP during transcription initiation by RNA polymerase II [PDF]
, 2016 Saccharomyces cerevisiae RNA polymerase (Pol) II locates transcription start sites (TSS) at TATA-containing promoters by scanning sequences downstream from the site of preinitiation complex formation, a process that involves the translocation of ...
Fishburn, James +2 more
core +2 more sources
Voiding Behavior and Efferent Bladder Function Altered in Mice Following Social Defeat but Not Witness Trauma [PDF]
, 2020 Psychological stress is associated with bladder dysfunction, however, the local bladder mechanisms affected are not well understood. This study aimed to determine how psychological stress, caused by social defeat or witness trauma, affects voiding ...
Chess-Williams, Russ +3 more
core +1 more source
Oculocutaneous albinism type 4: Novel compound heterozygous mutations in the SLC45A2 gene in a Chinese case. [PDF]
Mol Genet Genomic MedIn this study, we present a case with less pigmented hair and fairer than normal skin. Strabismus, hyperopia, astigmatism and the absence of iris pigment were found in his both eyes. Whole exome sequencing was performed in all samples, and Sanger sequencing was then used to verify the mutations. Compound heterozygous variants, c.1304C>A (p.S435Y) and c.
He D +6 more
europepmc +2 more sources