Results 91 to 100 of about 4,047,300 (256)

Abnormal grain growth in randomly-oriented fine grains in an Al–Mg–Sc–Zr alloy processed by laser-powder-bed-fusion

Materials Research Letters
In this work, we report a counter-intuitive activation of abnormal grain growth (AGG) in randomly-oriented fine grains (FGs) in an L-PBF Al–Mg–Sc–Zr alloy, which is unlikely from perspectives of curvature-driven grain growth, crystallographic texture or ...
Yanchi Chen, Xiang Chen, Han Chen, Yakai Xiao, Jing Dai, Yidan Chen, Yuchi Cui, Chengyi Dan, Zhe Chen, Xianfeng Li, Haowei Wang   +10 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

SIAM J. Matrix Analysis Appl

, 2013
The SIAM Journal on Matrix Analysis and Applications publishes research articles in matrix analysis and its applications and papers of interest to the numerical linear algebra community.
SIMONCINI, VALERIA
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Streamlined Sales Tax Governing Board Section 328 Best Practices Matrix

, 2014
A “best practice ” has been approved by the Streamlined Sales Tax Governing Board (SSTGB) for each of the products, procedures, services, or transactions identified in the chart below pursuant to Section 335 of the Streamlined Sales and Use Tax Agreement
Practices Matrix, Section Best
core  

Microstructure and nanoindentation behavior of Cu composites reinforced with graphene nanoplatelets by electroless co-deposition technique

Scientific Reports, 2017
A reduced graphene oxide/copper (RGO/Cu) composite was fabricated by a surfactant free, electroless co-deposition technique. The graphene oxide (GO) sheets were reduced and RGO homogeneous distributed into the copper matrix.
Qi Zhang, Zhenbo Qin, Qin Luo, Zhong Wu, Lei Liu, Bin Shen, Wenbin Hu   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Grewia polysaccharide as a pharmaceutical excipient in matrix tablets [PDF]

, 2011
Matrix-based tablets using different concentrations of grewia gum, and the model drug ibuprofen, were prepared using a wet granulation technique. Similar formulations were also prepared using HPMC, guar gum or ethyl cellulose as the polymer matrix.
Conway, Barbara R, Barbara R. Conway, Nep, Elijah I., Nep, E.I., Conway, Barbara R., Elijah I. Nep, Conway, Barbara R.; id_orcid   +6 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The impact of coaxial gas technology on the morphology of powder by gas atomisation and the additive manufactured mechanical performance

Virtual and Physical Prototyping
Metal powders are essential for additive manufacturing (AM), with their morphology significantly impacting the performance of AM components. Gas atomisation (GA) is a common method for producing metal powders due to its efficiency and cost-effectiveness.
Sheng Luo, Qianglong Wei, Yu Ouyang, An Wang, Zijue Tang, Hua Sun, Shimao Wang, Yi Wu, Haowei Wang, Hongze Wang   +9 more
doaj   +1 more source