Results 111 to 120 of about 3,440,012 (315)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Low-Temperature Soft-Cover-Assisted Hydrolysis Deposition of Large-Scale TiO2 Layer for Efficient Perovskite Solar Modules

Nano-Micro Letters, 2018
Perovskite solar cells with TiO2 electron transport layers exhibit power conversion efficiency (PCE) as high as 22.7% in single cells. However, the preparation process of the TiO2 layer is adopted by an unscalable method or requires high-temperature ...
Jinjin He, Enbing Bi, Wentao Tang, Yanbo Wang, Xudong Yang, Han Chen, Liyuan Han   +6 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heparin-fibronectin interactions in the development of extracellular matrix insolubility [PDF]

, 2017
During extracellular matrix (ECM) assembly, fibronectin (FN) fibrils are irreversibly converted into a detergent-insoluble form which, through FN's multi-domain structure, can interact with collagens, matricellular proteins, and growth factors to build a
Jean E. Schwarzbauer, Mia L. Huang, Benjamin Friedman, Friedman, Benjamin, Selwyn A. Williams, Raitman, Irene, Kamil Godula, Godula, Kamil, Schwarzbauer, Jean E, Irene Raitman, Williams, Selwyn A, Huang, Mia L   +11 more
core   +1 more source

Interactions between the discoidin domain receptor 1 and β1 integrin regulate attachment to collagen

Biology Open, 2013
Summary Collagen degradation by phagocytosis is essential for physiological collagen turnover and connective tissue homeostasis. The rate limiting step of phagocytosis is the binding of specific adhesion receptors, which include the integrins and ...
Lisa A. Staudinger, Stephen J. Spano, Wilson Lee, Nuno Coelho, Dhaarmini Rajshankar, Michelle P. Bendeck, Tara Moriarty, Christopher A. McCulloch   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The impact of coaxial gas technology on the morphology of powder by gas atomisation and the additive manufactured mechanical performance

Virtual and Physical Prototyping
Metal powders are essential for additive manufacturing (AM), with their morphology significantly impacting the performance of AM components. Gas atomisation (GA) is a common method for producing metal powders due to its efficiency and cost-effectiveness.
Sheng Luo, Qianglong Wei, Yu Ouyang, An Wang, Zijue Tang, Hua Sun, Shimao Wang, Yi Wu, Haowei Wang, Hongze Wang   +9 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

SINGULAR RANDOM MATRIX DECOMPOSITIONS: JACOBIANS. [PDF]

For a singular random matrix Y, we find the Jacobians associated with the following decompositions; QR, Polar, Singular Value (SVD), L´U, L´DM and modified QR (QDR).
Graciela González-Farías, José A. Díaz-García   +1 more
core  

Hierarchical pore engineering of lignocellulose-based carbon materials for electric double-layer capacitors

Nano Research
Lignocellulose is an ideal precursor for supercapacitor electrodes due to its diverse structures and abundant availability. For supercapacitors, particularly electric double-layer capacitors (EDLCs), pore structure is critical.
Yanyu Li, Huyan Shen, Yiyan Zhu, Imran Zada, Fang Song, Qinglei Liu, Hui Pan, Shenmin Zhu, Juan Li, Bohumil Kasal, Yao Li, Di Zhang   +11 more
doaj   +1 more source